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The Neurocognitive Function and Neuroimaging Characteristics between Age-Associated Memory Impairment and Mild Cognitive Impairment

 Ji-Hye Kim  ;  Ji-Won Lee 
 Korean Journal of Clinical Geriatrics (임상노인의학회지), Vol.20(1) : 18-25, 2019 
Journal Title
 Korean Journal of Clinical Geriatrics (임상노인의학회지) 
Issue Date
Age-Related Memory Disorders ; Mild Cognitive Impairment ; Neuroimaging
Background: Age-associated memory impairment (AAMI) and mild cognitive impairment (MCI) were considered to have a positive correlation with early dementia status, reflecting the decline in objective cognitive function. Studies results exploring the characteristics of AAMI and MCI remain mixed. We investigated the characteristics of AAMI and MCI using neuroimaging and neurocognitive function in healthy Korean adults. Methods: This cross-sectional study analyzed a total of 14 participants who visited single health promotion center. AAMI and MCI was defined via questionnaires. Participants were classified into three groups based on neurocognitive status: normal, AAMI, MCI. We conducted either Kruskal-Wallis or chi-square test to compare the neuroimaging characteristics between three groups; Mann-Whitney U test was applied for the within-group analysis. Kruskal-Wallis test was used to investigate the neurocognitive function between three groups. Results: In the case of AAMI and MCI, there were partial metabolic decreases in various parts such as temporal lobe, frontal lobe, parietal lobe and cerebellum. Profound disparities in metabolic decrease in parietal lobe were observed among three groups (P=0.049). In the MMSE characteristics, MCI group showed marked deterioration in attention (P=0.030), and decreased in more various cognitive domains than AAMI group. Conclusion: The distinct neuroimaging characteristics were observed among three groups. The deficit of neurocognitive function was more prominent in attention in MCI group.
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7. Others (기타) > Dept. of Health Promotion (건강의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ji-Hye(김지혜) ORCID logo https://orcid.org/0000-0002-5719-8180
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
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