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Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling

Authors
 Sung-Jin Kim  ;  Seok Jun Moon  ;  Jeong Taeg Seo 
Citation
 International Journal of Oral Biology, Vol.44(1) : 1-7, 2019 
Journal Title
 International Journal of Oral Biology 
ISSN
 1226-7155 
Issue Date
2019
Keywords
Osteoporosis ; Medications ; Osteoblast ; Osteoclast ; Bone
Abstract
Osteoporosis is a common disease characterized by bone mass reduction, leading to an increased risk of bone fracture, and it is caused by an imbalance of osteoblastic bone formation and osteoclastic bone resorption. Current osteoporosis drugs aim to reduce the risk of bone fracture, either by increasing osteoblastic bone formation or decreasing osteoclastic bone resorption. However, osteoblasts and osteoclasts are closely coupled, such that any reagent altering the differentiation or activity of one eventually affects the other. This tight coupling between osteoblasts and osteoclasts not only limits the therapeutic efficacy but also threatens the safety of osteoporosis drugs. This review will discuss the biological mechanisms of action of currently approved medications for osteoporosis treatment, focusing on the osteoblast–osteoclast coupling.
Files in This Item:
T201903853.pdf Download
DOI
10.11620/IJOB.2019.44.1.1
Appears in Collections:
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Jin(김성진) ORCID logo https://orcid.org/0000-0003-4115-0403
Moon, Seok Jun(문석준) ORCID logo https://orcid.org/0000-0001-7282-2888
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/173063
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