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Biological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling

DC Field Value Language
dc.contributor.author김성진-
dc.contributor.author문석준-
dc.contributor.author서정택-
dc.date.accessioned2019-12-18T00:28:14Z-
dc.date.available2019-12-18T00:28:14Z-
dc.date.issued2019-
dc.identifier.issn1226-7155-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/173063-
dc.description.abstractOsteoporosis is a common disease characterized by bone mass reduction, leading to an increased risk of bone fracture, and it is caused by an imbalance of osteoblastic bone formation and osteoclastic bone resorption. Current osteoporosis drugs aim to reduce the risk of bone fracture, either by increasing osteoblastic bone formation or decreasing osteoclastic bone resorption. However, osteoblasts and osteoclasts are closely coupled, such that any reagent altering the differentiation or activity of one eventually affects the other. This tight coupling between osteoblasts and osteoclasts not only limits the therapeutic efficacy but also threatens the safety of osteoporosis drugs. This review will discuss the biological mechanisms of action of currently approved medications for osteoporosis treatment, focusing on the osteoblast–osteoclast coupling.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherHarn Rim Won Printing Co.-
dc.relation.isPartOfInternational Journal of Oral Biology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBiological characteristics of osteoporosis drugs: the effect of osteoblast–osteoclast coupling-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentOthers-
dc.contributor.googleauthorSung-Jin Kim-
dc.contributor.googleauthorSeok Jun Moon-
dc.contributor.googleauthorJeong Taeg Seo-
dc.identifier.doi10.11620/IJOB.2019.44.1.1-
dc.contributor.localIdA00586-
dc.contributor.localIdA01358-
dc.contributor.localIdA01358-
dc.contributor.localIdA01905-
dc.contributor.localIdA01905-
dc.relation.journalcodeJ01144-
dc.subject.keywordOsteoporosis-
dc.subject.keywordMedications-
dc.subject.keywordOsteoblast-
dc.subject.keywordOsteoclast-
dc.subject.keywordBone-
dc.contributor.alternativeNameKim, Sung Jin-
dc.contributor.affiliatedAuthor김성진-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor문석준-
dc.contributor.affiliatedAuthor서정택-
dc.contributor.affiliatedAuthor서정택-
dc.citation.volume44-
dc.citation.number1-
dc.citation.startPage1-
dc.citation.endPage7-
dc.identifier.bibliographicCitationInternational Journal of Oral Biology, Vol.44(1) : 1-7, 2019-
dc.identifier.rimsid64886-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Others (기타) > 1. Journal Papers

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