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경증 및 중등도 본태성 고혈압 환자에서 Candesartan Cilexetil의 강압효과 및 임상적 안전성에 대한 연구.

Other Titles
 A Clinical Study on Anti-Hypertensive Effect and Safety of Candesartan Cilexetil (Atacand) in Mild to Moderate Hypertensive Patients 
 강석민  ;  정남식  ;  최동훈  ;  안신기  ;  임세중  ;  하종원  ;  장양수  ;  심원흠  ;  조승연  ;  김성순  ;  이선호 
 Korean Circulation Journal (순환기), Vol.29(9) : 937-943, 1999 
Journal Title
Issue Date
Hypertension ; Angiotensin II receptor blocker ; Candesartan cilexetil
Background and Objectives : Candesartan cilexetil (Atacand ), a selective type I angiotensin II receptor blocker, has recently been introduced as a new antihypertensive agent. We evaluated its anti-hypertensive effect and safety in mild to moderate hypertensive patients.

Materials and Methods : Candesartan cilexetil, 8 mg or 16 mg, was administered once a day over 8 weeks period in the patients with mild to moderate hypertension (25 male, 26 female, mean age: 53.5±1.2 years). For safety evaluation, laboratory tests were performed before and after treatment with candesartan cilexetil. Changes in blood pressure, heart rate and electrocardiogram were also observed.

Results : 1) The mean blood pressures in the sitting position were systolic 164.1±2.1 mmHg and diastolic 106.3±0.8 mmHg before treatment, which were lowered to 135.4±2.0 mmHg and 89.1±1.1 mmHg, repectively after 8 weeks of treatment (p<0.05). 2) Candesartan cilexetil had a significant dose-depen-dent antihypertensive effect for diastolic pressure in 35 patients (8 mg:97.8±0.9 mmHg, 16 mg:91.3±1.1 mmHg, p<0.05). 3) Heart rate was not significantly changed before and after treatment during the treatment with candesartan cilexetil (72.2±1.2/min vs. 72.0±1.3/min;p>0.05). 4) Laboratory tests revealed no significant abnormality by the treatment with candesartan cilexetil. 5) Left ventricular hypertrophy by ECG criteria detected in 3 cases disappeared after treatment with candesartan cilexetil. 6) No significant side effects were observed during the treatment period.

Conclusion : Candesartan cilexetil, 8 mg or 16 mg, once a day is an effective and well tolerated antihypertensive treatment. It has a significant dose-dependent antihypertensive effect.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo
Ahn, Shin Ki(안신기) ORCID logo
Rim, Se Joong(임세중) ORCID logo
Jang, Yang Soo(장양수) ORCID logo
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo
Ha, Jong Won(하종원) ORCID logo
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