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경증 및 중등도 본태성 고혈압 환자에서 Candesartan Cilexetil의 강압효과 및 임상적 안전성에 대한 연구.

Other Titles
 A Clinical Study on Anti-Hypertensive Effect and Safety of Candesartan Cilexetil (Atacand) in Mild to Moderate Hypertensive Patients 
 강석민  ;  정남식  ;  최동훈  ;  안신기  ;  임세중  ;  하종원  ;  장양수  ;  심원흠  ;  조승연  ;  김성순  ;  이선호 
 Korean Circulation Journal (순환기), Vol.29(9) : 937-943, 1999 
Journal Title
 Korean Circulation Journal (순환기) 
Issue Date
Hypertension ; Angiotensin II receptor blocker ; Candesartan cilexetil
Background and Objectives : Candesartan cilexetil (Atacand ), a selective type I angiotensin II receptor blocker, has recently been introduced as a new antihypertensive agent. We evaluated its anti-hypertensive effect and safety in mild to moderate hypertensive patients. Materials and Methods : Candesartan cilexetil, 8 mg or 16 mg, was administered once a day over 8 weeks period in the patients with mild to moderate hypertension (25 male, 26 female, mean age: 53.5±1.2 years). For safety evaluation, laboratory tests were performed before and after treatment with candesartan cilexetil. Changes in blood pressure, heart rate and electrocardiogram were also observed. Results : 1) The mean blood pressures in the sitting position were systolic 164.1±2.1 mmHg and diastolic 106.3±0.8 mmHg before treatment, which were lowered to 135.4±2.0 mmHg and 89.1±1.1 mmHg, repectively after 8 weeks of treatment (p<0.05). 2) Candesartan cilexetil had a significant dose-depen-dent antihypertensive effect for diastolic pressure in 35 patients (8 mg:97.8±0.9 mmHg, 16 mg:91.3±1.1 mmHg, p<0.05). 3) Heart rate was not significantly changed before and after treatment during the treatment with candesartan cilexetil (72.2±1.2/min vs. 72.0±1.3/min;p>0.05). 4) Laboratory tests revealed no significant abnormality by the treatment with candesartan cilexetil. 5) Left ventricular hypertrophy by ECG criteria detected in 3 cases disappeared after treatment with candesartan cilexetil. 6) No significant side effects were observed during the treatment period. Conclusion : Candesartan cilexetil, 8 mg or 16 mg, once a day is an effective and well tolerated antihypertensive treatment. It has a significant dose-dependent antihypertensive effect.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Rim, Se Joong(임세중) ORCID logo https://orcid.org/0000-0002-7631-5581
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
Chung, Nam Sik(정남식)
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
Ha, Jong Won(하종원) ORCID logo https://orcid.org/0000-0002-8260-2958
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