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경증 및 중등도 본태성 고혈압 환자에서 Candesartan Cilexetil의 강압효과 및 임상적 안전성에 대한 연구.
DC Field | Value | Language |
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dc.contributor.author | 하종원 | - |
dc.contributor.author | 강석민 | - |
dc.contributor.author | 정남식 | - |
dc.contributor.author | 최동훈 | - |
dc.contributor.author | 임세중 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 안신기 | - |
dc.date.accessioned | 2019-11-26T01:14:23Z | - |
dc.date.available | 2019-11-26T01:14:23Z | - |
dc.date.issued | 1999 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/172854 | - |
dc.description.abstract | Background and Objectives : Candesartan cilexetil (Atacand ), a selective type I angiotensin II receptor blocker, has recently been introduced as a new antihypertensive agent. We evaluated its anti-hypertensive effect and safety in mild to moderate hypertensive patients. Materials and Methods : Candesartan cilexetil, 8 mg or 16 mg, was administered once a day over 8 weeks period in the patients with mild to moderate hypertension (25 male, 26 female, mean age: 53.5±1.2 years). For safety evaluation, laboratory tests were performed before and after treatment with candesartan cilexetil. Changes in blood pressure, heart rate and electrocardiogram were also observed. Results : 1) The mean blood pressures in the sitting position were systolic 164.1±2.1 mmHg and diastolic 106.3±0.8 mmHg before treatment, which were lowered to 135.4±2.0 mmHg and 89.1±1.1 mmHg, repectively after 8 weeks of treatment (p<0.05). 2) Candesartan cilexetil had a significant dose-depen-dent antihypertensive effect for diastolic pressure in 35 patients (8 mg:97.8±0.9 mmHg, 16 mg:91.3±1.1 mmHg, p<0.05). 3) Heart rate was not significantly changed before and after treatment during the treatment with candesartan cilexetil (72.2±1.2/min vs. 72.0±1.3/min;p>0.05). 4) Laboratory tests revealed no significant abnormality by the treatment with candesartan cilexetil. 5) Left ventricular hypertrophy by ECG criteria detected in 3 cases disappeared after treatment with candesartan cilexetil. 6) No significant side effects were observed during the treatment period. Conclusion : Candesartan cilexetil, 8 mg or 16 mg, once a day is an effective and well tolerated antihypertensive treatment. It has a significant dose-dependent antihypertensive effect. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | Korean | - |
dc.publisher | 대한심장학회 | - |
dc.relation.isPartOf | Korean Circulation Journal (순환기) | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 경증 및 중등도 본태성 고혈압 환자에서 Candesartan Cilexetil의 강압효과 및 임상적 안전성에 대한 연구. | - |
dc.title.alternative | A Clinical Study on Anti-Hypertensive Effect and Safety of Candesartan Cilexetil (Atacand) in Mild to Moderate Hypertensive Patients | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학교실) | - |
dc.contributor.googleauthor | 강석민 | - |
dc.contributor.googleauthor | 정남식 | - |
dc.contributor.googleauthor | 최동훈 | - |
dc.contributor.googleauthor | 안신기 | - |
dc.contributor.googleauthor | 임세중 | - |
dc.contributor.googleauthor | 하종원 | - |
dc.contributor.googleauthor | 장양수 | - |
dc.contributor.googleauthor | 심원흠 | - |
dc.contributor.googleauthor | 조승연 | - |
dc.contributor.googleauthor | 김성순 | - |
dc.contributor.googleauthor | 이선호 | - |
dc.identifier.doi | 10.4070/kcj.1999.29.9.937 | - |
dc.contributor.localId | A04257 | - |
dc.relation.journalcode | J01953 | - |
dc.identifier.eissn | 1738-5555 | - |
dc.subject.keyword | Hypertension | - |
dc.subject.keyword | Angiotensin II receptor blocker | - |
dc.subject.keyword | Candesartan cilexetil | - |
dc.contributor.alternativeName | Ha, Jong Won | - |
dc.contributor.affiliatedAuthor | 하종원 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 937 | - |
dc.citation.endPage | 943 | - |
dc.identifier.bibliographicCitation | Korean Circulation Journal (순환기), Vol.29(9) : 937-943, 1999 | - |
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