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가성부갑상선기능저하증 환아의 구강내 증상에 관한 증례보고

Other Titles
 DENIAL CHARACTERISTICS OF PSEUDOHYPOPARATHYROIDISM : CASE REPORT 
Authors
 장지영  ;  이제호  ;  최병재  ;  이종갑 
Citation
 Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지), Vol.26(3) : 486-491, 1999 
Journal Title
 Journal of the Korean Academy of Pediatric Dentistry (대한소아치과학회지) 
ISSN
 1226-8496 
Issue Date
1999
Keywords
Blood calcium level ; Enamel hypoplasia ; Pseudohypoparathyroidism
Abstract
Hypoparathyroidism has abnormally decreased secretion of parathyroid hormon which responds to the blood calcium level. Wherease, Pseudohypoparathyroidism has normal activity of thyroid hormon, but end-organs, such as urinary tract and osteoclast, do not respond to parathyroid hormon. The cause of this disease is due to the mutation of Guanine stimulating(Gs) protein regulating Gs gene, which is the receptor to this hormon. Pseudohypoparathyroidism is usually noted before 20 years old on average of 8-9 years old. The clinical features of this disease includes delayed growth and development, round face, obesity, soft tissue calcification, ectopic ossification, shortening of metacarpals and metatarsals by epiphyseal closure in advance of age. The mutation of Gs gene which are found in brain, endocrine organs, and chondrocytes is the cause of those features. Reaction to Glucagon, gonadal hormon, and thyroid stimulating hormon is not expected in both cases. The common dental manifestations include enamel hypoplasia, delayed eruption, agenesis of tooth, hypodontia, dysplastic short roots, widened pulpal space, microdontia, intrapulpal calcification, and malocclusion are also often reported. This case which is diagnosed to Pseudohypoparathyroidism showed short and under-developed root of permanent troth, delayed eruption, and non-eruption of premolars and molars. And morphogenesis imperfecta of first and second premolars were also found.
Files in This Item:
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Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Pediatric Dentistry (소아치과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Byung Jai(최병재)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172680
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