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가와사끼병 환아에서 NRAMP-1 유전자의 발현

Other Titles
 NRAMP 1 Gene Expression in Patients with Kawasaki Disease 
 김현영  ;  김동수  ;  신전수 
 Pediatric Allergy and Respiratory Disease (소아알레르기 호흡기학회지), Vol.10(2) : 153-164, 2000 
Journal Title
Pediatric Allergy and Respiratory Disease(소아알레르기 호흡기학회지)
Issue Date
Kawasaki disease ; NRAMP1 ; genetics
Purpose : Kawasaki disease(KD) is considered to be an immunologic disease, although the exact etiology of the disease is still unknown. It is well known that the erythema on the BCG injected site are observed in patients with KD. In mouse, bcg gene was reported to be involved in the natural immune response to Mycobacterium. The correspondent gene in human, NRAMP1, is studied recently for its role and function. This study was to investigate whether the erythema developed on BCG injected site in patients with KD is related to NRAMPI gene activation. Methods : Ten patients diagnosed as KD, 10 febrile controls and 10 healthy normal controls were enrolled in the study. Total RNA of PBMC was isolated and used to synthesize cDNA. RT-PCR was done and amplified products were subjected to electrophoresis on 1.5% agarose gel electrophoresis. The bands were quantified with densitometry and the values were corrected according to β-actin values. Results : The NRAMPI expression was notably increased in patients with acute and subacute stage of KD and there was no difference in the degree of expression between the two groups. NRAMP1 expression was also increased in febrile control groups and was not different from patients group. Conclusion : Increased NRAMPI expression in KD is suggested to be developed for the expression of heat shock protein, and not to be the specific finding of KD.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jeon Soo(신전수) ORCID logo https://orcid.org/0000-0002-8294-3234
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