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Capsaicin에 의해 유도되는 마우스 해마신경세포의 아폽토시스에 미치는 agmatine의 영향

Other Titles
 The Effects of Agmatine on Apoptosis Induced by Capsaicin in Mouse Hippocamal Neuron 
Authors
 이성호  ;  오성한  ;  빅경아  ;  이원택  ;  이종은 
Citation
 Korean Journal of Anatomy (대한해부학회지), Vol.33(6) : 733-742, 2000 
Journal Title
 Korean Journal of Anatomy (대한해부학회지) 
ISSN
 1225-1305 
Issue Date
2000
Keywords
CAPSAICIN ; CA2+ ; NOS ; AGMATINE ; Ca2+ ; Hippocampal Neuron ; Apoptosis
Abstract
Capsaicin, the pungent algesic substance of the red pepper is known to be a neurotoxic substance, interrupting the pain conducting pathway. Until recently the neurotoxic effects of capsaicin in adult animals were thought to be limited to peripheral nervous system. Several reports suggest the possibility of central nervous system changes after capsaicin administration to the adult rats. To determine the effects of capsaicin in central nervous system, morphological and biochemical changes were investigated in mouse primary cultured hippocampal neuron. After capsaicin treatment, hippocampal neurons died in dose-and time-dependent manner. Nuclear fragmentation showed that neuronal cell death induced by capsaicin is apoptosis rather than necrosis. And capsaicin treated neurons were stained by cobalt staining and nitric oxide synthase (NOS) histochemical staining. These results indicated that capsaicin induced influx of cation ions. Because neuronal NOS is activated by Ca(2+), capsaicin induced influx of Ca(2+). Agmatine, which is competitive inhibitor of NOS, reduced cell death induced by capsaicin. It seems likely that the process of hippocampal neuron cell death induced by capsaicin correlates with the activation of NOS by Ca(2+) influx.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
Yonsei Authors
Park, Kyung Ah(박경아)
Lee, Won Taek(이원택) ORCID logo https://orcid.org/0000-0001-7348-9562
Lee, Jong Eun(이종은) ORCID logo https://orcid.org/0000-0001-6203-7413
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172419
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