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위암에서 핵산 함량 양상과 휴지기 세포 분획의 예후인자로서의 의의

Other Titles
 Prognostic Significance of DNA Content and S-Phase Fraction in Gastric Carcinomas 
 황수경  ;  이준호  ;  노성훈  ;  이강영  ;  최승호  ;  민진식 
 Journal of the Korean Surgical Society (대한외과학회지), Vol.59(5) : 602-608, 2000 
Journal Title
 Journal of the Korean Surgical Society (대한외과학회지) 
Issue Date
GASTRIC CARCINOMA ; Prognosis ; DNA flow cytometry
Purpose: DNA flow cytometry is a simple and easy method to assess the DNA content and the cell-cycle distribution of a tumor cell. The prognostic significance of the DNA content and the S-phase fraction in a gastric carcinoma has been controversial. The purpose of this study was to evaluate the prognostic significance of the nuclear DNA content and the S-phase fraction in patients with a gastric carcinoma. Methods: Between May 1995 and March 1996, 94 patients who were underwent a gastric resection for a gastric carcinoma were evaluated with DNA flow cytometry. Of them, 88 patients underwent a gastric resection with curative intent. The relationship of variable clinicopathological factors and of recurrence pattern to survival and nuclear DNA content were assessed. Results: The mean age was 55 years. 55 patients (58.5%) exbitied diploidy and 39 patients (41.5%) aneuploidy. There was no relationship between the clinicopathological factors and either the ploidy pattem or the S-phase fraction. Though the recurrence and its pattem were not different between the two ploidy group (p=0.860, 0.137), diploidy tended to recur locoregionally and aneuploidy hematogenously. Conclusion: The ploidy pattern was a significant prognostic factor in gastric carcinomas, but should be interpreted carefully.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Lee, Kang Young(이강영)
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