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MUC5AC의 눈물층에서의 존재 양상

Other Titles
 The characteristics of MUC5AC in the corneal tear film 
Authors
 정승은  ;  김소영  ;  서경률  ;  박중원  ;  정수연  ;  성제경  ;  김응권 
Citation
 Journal of the Korean Ophthalmological Society (대한안과학회지), Vol.41(6) : 1304-1309, 2000 
Journal Title
JOURNAL OF THE KOREAN OPHTHALMOLOGICAL SOCIETY(대한안과학회지)
ISSN
 0378-6471 
Issue Date
2000
Keywords
Cornea ; Tear film ; Mucin ; MUC5AC
Abstract
The mucous layer located on the cornea epithelial surface is mainly composed of mucin.It is unique in being composed of a central protein back bone surrounded by an outermost dense oligosaccharide matrix, yet its pre-cise composition is still unknown. Conjunctival goblet cells have been known to express the mucin MUC5AC. We attempted to reveal the presence of the secretory mucin MUC5AC as a component of the mucous layer in the rabbit corneal tear film. An antibody to a MUC5AC peptide was used to detect the MUC5AC mucin present in the tear film by immunohistochemistry. Human conjuncti-val impression cytology and immunohistochemistry were done with the same antibody. The MUC5AC mucin was observed in the precorneal tear film and con-junctival goblet cells by immunohistochemistry.The MUC5AC mucin is a component of the mucous layer and is produced by the goblet cells of con-junctiva.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/172242
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