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급성 식도정맥류 출혈 환자에서 Somatostatin과 Vasopressin의 치료효과 비교: A Prospective Randomized Trial.

Other Titles
 Comparison of Somatostatin and Vasopressin in the Control of Acute Esophageal Variceal Hemorrhage : A Prospective Randomized Trial 
Authors
 전재윤  ;  정정일  ;  백용한  ;  이천균  ;  최병현  ;  이관식  ;  문병수  ;  한광협  ;  문영명  ;  김동기 
Citation
 Korean Journal of Hepatology (대한간학회지), Vol.6(4) : 468-473, 2000 
Journal Title
 Korean Journal of Hepatology (대한간학회지) 
ISSN
 1738-222X 
Issue Date
2000
Keywords
Somatostatin ; Vasopressin ; Esophageal variceal hemorrhage
Abstract
Background/ A ims : Although endoscopic band ligation or injection sclerotherapy are the current standard therapies for bleeding esophageal varices, the best method for initial control is unclear . The aim of this prospective study was to compare the efficacy and toxicity of somatostatin and vasopressin in the management of esophageal variceal hemorrhage. Methods : From March, 1997 to September , 1998, 28 consecutive cirrhotic patients admitted to the Yon sei Medical Center because of active variceal bleeding were included in this trial. The patient s were randomized to receive either somatostatin (15 patient s) or vasopressin (13 patient s) for 48 hours. Results : There were nosignificant differences between the two treatment groups in relation to Child' s classification, amount of bleeding before randomization and unit s of blood transfu sed during therapy . Initial control of bleeding was achieved in 13 (86.7%) patient s receiving somatostatin and in 10 (76.9%) of those treated with vasopres sin. However , two patient s in the somatostatin group and two in the vasopressin group bled again during treatment . Therefore complete control of bleeding during the 48 hour s of therapy was achieved in 11 (73.4%) patient s treated with somatostatin and in eight (61.5%) of those receiving vasopressin. Differences were observed in complication s associated with each therapy. Vasopressin produced complications in four patient s (chest pain in two, hyperten sion in one and hyponatremia- induced seizure in one) while somatostatin produced minor complication in one patient. Conclusions : This study suggest s that somatostatin is efficaciou s in controlling acute hemorrhage from esophageal varices and has a lower risk of adver se effect s than vasopres sin.(Korean J Hepatol 2000 ;6 :468 - 473)
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jeong Ho(김정호) ORCID logo https://orcid.org/0000-0003-2479-0548
Paik, Yong Han(백용한)
Lee, Kwan Sik(이관식) ORCID logo https://orcid.org/0000-0002-3672-1198
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171987
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