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Uterine artery Doppler velocimetry in the prediction of adverse obstetric outcomes in unexplained MSAFP elevations

Authors
 Jae Eun Chung  ;  Jae Sung Cho  ;  Sung Shik Han  ;  Yong Won Park  ;  Jae Wook Kim 
Citation
 Yonsei Medical Journal, Vol.41(1) : 17-21, 2000 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2000
MeSH
Adult ; Arteries/diagnostic imaging ; Female ; Forecasting ; Humans ; Incidence ; Pregnancy/blood* ; Pregnancy Complications*/epidemiology ; Ultrasonography ; Uterus/blood supply* ; Uterus/diagnostic imaging* ; alpha-Fetoproteins/analysis*
Keywords
Unexplained elevated maternal serum-fetoprotein ; uterine artery Doppler Velocimetry ; adverse pregnancy outcome
Abstract
Unexplained maternal serum-fetoprotein (MSAFP) elevation has been known to be associated with adverse obstetric outcomes, however it is not sufficiently useful as a screening test. This study was undertaken to determine whether uterine artery Doppler velocimetry could define a subset of patients with an elevated MSAFP level in whom complications of pregnancy might develop. The subjects included 179 women between 26 and 28 weeks' gestation with MSAFP > or = 2.5 multiples of the median, in whom either the presence of an early diastolic notch or a resistance index 0.6 was considered as an abnormal Doppler velocimetry finding. Those subjects who displayed abnormal Doppler velocimetry findings showed an increased incidence of preeclampsia, preterm birth, IUGR, and IUFD compared to those subjects with only elevated MSAFP (p < 0.05). No differences were observed in the incidence of LBW. Positive predictive values of adverse obstetric outcomes were significantly higher in the group having both elevated MSAFP and abnormal Doppler velocimetry compared to the group with only elevated MSAFP (p < 0.05). Uterine artery Doppler velocimetry in the second trimester can improve the value of unexplained MSAFP elevation in the prediction of adverse obstetric outcomes.
Files in This Item:
T200003391.pdf Download
DOI
10.3349/ymj.2000.41.1.17
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Yong Won(박용원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171930
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