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Diffuse cerebrospinal cliomatosis with extensive leptomeningeal spread

Authors
 Jong Yup Bae  ;  Byung Ok Choi  ;  il nam Sun Woo  ;  Dong Ik Kim  ;  Sang Ho Cho  ;  Tai Seung Kim 
Citation
 Yonsei Medical Journal, Vol.41(4) : 517-521, 2000 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2000
MeSH
Adolescent ; Brain/pathology ; Cell Division ; Diagnosis, Differential ; Female ; Humans ; Magnetic Resonance Imaging ; Meninges/pathology* ; Neoplasms, Neuroepithelial/diagnosis ; Neoplasms, Neuroepithelial/pathology* ; Spinal Cord/pathology
Keywords
Cerebrospinal gliomatosis ; subarachnoidal ; leptomeningeal ; meningoencephalitis ; flow cytometry
Abstract
A case of diffuse cerebrospinal gliomatosis with extensive leptomeningeal spread is presented. The patient, an 18-year-old girl, was admitted due to progressive weakness and paresthesia of both legs, following rapid neuropsychiatric deterioration. An initial magnetic resonance imaging (MRI) study of the T-spine showed diffuse high signal intensities from T9 to T12 spinal cords on a T2 sagittal image and diffuse cord bulging at T1WI. This suggested an inflammatory lesion such as tuberculosis or fungal meningoencephalitis. A limited autopsy was performed. A microscopic examination revealed multifocal GFAP-positive astrocytic proliferations that were low grade astrocytoma in the cerebral leptomeninges, parietal, occipital and temporal lobes and anaplastic astrocytoma in the spinal cord and spinal leptomeninges. The high proliferative indices of the spinal lesion and aneuploidy correspond to a diagnosis of malignant astrocytoma and a rapid fatal clinical course.
Files in This Item:
T200003093.pdf Download
DOI
10.3349/ymj.2000.41.4.517
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171921
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