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Transeint improvement of pyrucate metabolism after coenzyme Q therapy in Kearns-Sayre syndrome : MRS study

Authors
 Chulhee Choi  ;  Il-Nam Sunwoo  ;  Hyun-Sook Kim  ;  Dong-Ik Kim 
Citation
 Yonsei Medical Journal, Vol.41(5) : 676-679, 2000 
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
 0513-5796 
Issue Date
2000
MeSH
Adolescent ; Brain/drug effects ; Brain/metabolism ; Female ; Humans ; Kearns-Sayre Syndrome/diagnosis ; Kearns-Sayre Syndrome/drug therapy* ; Kearns-Sayre Syndrome/metabolism* ; Lactic Acid/metabolism ; Magnetic Resonance Spectroscopy* ; Pyruvic Acid/metabolism* ; Treatment Outcome ; Ubiquinone/therapeutic use*
Keywords
Kearns-Sayre Syndrome ; MRS ; CoQ ; Lactate
Abstract
Coenzyme Q therapy has been used to support metabolic derangements in patients with mitochondrial encephalomyopathies. Biochemical analysis of the living human brain can be performed by magnetic resonance spectroscopy (MRS). We report upon a KSS patient who was serially imaged with localized proton MRS to monitor the efficacy of CoQ treatment. A 17-year-old girl with KSS was serially imaged with localized proton MRS performed on a GE 1.5 T SIGNA MRI/MRS system. The elevated lactate contents of lesions decreased after one month of CoQ therapy but were re-elevated 10 months after treatment. We conclude that MRS presents us with a powerful tool for monitoring the effects of therapeutic trials in mitochondrial encephalomyopathies.
Files in This Item:
T200002556.pdf Download
DOI
10.3349/ymj.2000.41.5.676
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Ik(김동익)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171909
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