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Evaluation of calcification in porcine valves treated by ultraviolet ray and glutaraldehyde

Authors
 Hwal Suh  ;  Jong-Cheol Park 
Citation
 Materials Science & Engineering C - Materials for Biological Applications, Vol.13(1~2) : 65-73, 2000 
Journal Title
 Materials Science & Engineering C - Materials for Biological Applications 
ISSN
 0928-4931 
Issue Date
2000
Keywords
Porcine valve ; Glutaraldehyde ; Ultraviolet ray ; Calcification ; In vitro flow type
Abstract
Porcine aortic valve, of which tissue structural collagen matrix is cross-linked by glutaraldehyde (GA) to enhance mechanical property, is widely used in clinics, but gradual calcification occurs after implantation. Cross-linking the valve by 24 h of ultraviolet (UV) ray irradiation that induces collagen fibrous cross-link resulted in less calcium deposition than GA-pretreated leaflets. After 3 days, calcium level in GA-treated leaflets was distinctively higher than in leaflets cross-linked by UV irradiation for 24 h and in the non-treated control leaflets. The exposure time of UV irradiation was not significantly correlated with the extent of calcification. In all the test groups, molar [Ca]/[P] ratio gradually decreased as time went by, and UV-irradiated and control leaflets demonstrated molar [Ca]/[P] ratio close to apatite as the predominant mineral phase and GA-treated leaflet reached the similar molar ratio after 30 days. In animal experiment, the leaflet treated by UV irradiation demonstrated a stable surface without calcification after 2 months of implantation.
Full Text
https://www.sciencedirect.com/science/article/pii/S0928493100001788
DOI
10.1016/S0928-4931(00)00178-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
Park, Jong Chul(박종철) ORCID logo https://orcid.org/0000-0003-0083-5991
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171801
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