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Evaluation of calcification in porcine valves treated by ultraviolet ray and glutaraldehyde

DC FieldValueLanguage
dc.contributor.author박종철-
dc.date.accessioned2019-11-11T05:20:58Z-
dc.date.available2019-11-11T05:20:58Z-
dc.date.issued2000-
dc.identifier.issn0928-4931-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171801-
dc.description.abstractPorcine aortic valve, of which tissue structural collagen matrix is cross-linked by glutaraldehyde (GA) to enhance mechanical property, is widely used in clinics, but gradual calcification occurs after implantation. Cross-linking the valve by 24 h of ultraviolet (UV) ray irradiation that induces collagen fibrous cross-link resulted in less calcium deposition than GA-pretreated leaflets. After 3 days, calcium level in GA-treated leaflets was distinctively higher than in leaflets cross-linked by UV irradiation for 24 h and in the non-treated control leaflets. The exposure time of UV irradiation was not significantly correlated with the extent of calcification. In all the test groups, molar [Ca]/[P] ratio gradually decreased as time went by, and UV-irradiated and control leaflets demonstrated molar [Ca]/[P] ratio close to apatite as the predominant mineral phase and GA-treated leaflet reached the similar molar ratio after 30 days. In animal experiment, the leaflet treated by UV irradiation demonstrated a stable surface without calcification after 2 months of implantation.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfMaterials Science & Engineering C - Materials for Biological Applications-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEvaluation of calcification in porcine valves treated by ultraviolet ray and glutaraldehyde-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorHwal Suh-
dc.contributor.googleauthorJong-Cheol Park-
dc.identifier.doi10.1016/S0928-4931(00)00178-8-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ02186-
dc.identifier.eissn0928-4931-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0928493100001788-
dc.subject.keywordPorcine valve-
dc.subject.keywordGlutaraldehyde-
dc.subject.keywordUltraviolet ray-
dc.subject.keywordCalcification-
dc.subject.keywordIn vitro flow type-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthor박종철-
dc.citation.volume13-
dc.citation.number1~2-
dc.citation.startPage65-
dc.citation.endPage73-
dc.identifier.bibliographicCitationMaterials Science & Engineering C - Materials for Biological Applications, Vol.13(1~2) : 65-73, 2000-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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