Cited 8 times in
Evaluation of calcification in porcine valves treated by ultraviolet ray and glutaraldehyde
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.date.accessioned | 2019-11-11T05:20:58Z | - |
dc.date.available | 2019-11-11T05:20:58Z | - |
dc.date.issued | 2000 | - |
dc.identifier.issn | 0928-4931 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/171801 | - |
dc.description.abstract | Porcine aortic valve, of which tissue structural collagen matrix is cross-linked by glutaraldehyde (GA) to enhance mechanical property, is widely used in clinics, but gradual calcification occurs after implantation. Cross-linking the valve by 24 h of ultraviolet (UV) ray irradiation that induces collagen fibrous cross-link resulted in less calcium deposition than GA-pretreated leaflets. After 3 days, calcium level in GA-treated leaflets was distinctively higher than in leaflets cross-linked by UV irradiation for 24 h and in the non-treated control leaflets. The exposure time of UV irradiation was not significantly correlated with the extent of calcification. In all the test groups, molar [Ca]/[P] ratio gradually decreased as time went by, and UV-irradiated and control leaflets demonstrated molar [Ca]/[P] ratio close to apatite as the predominant mineral phase and GA-treated leaflet reached the similar molar ratio after 30 days. In animal experiment, the leaflet treated by UV irradiation demonstrated a stable surface without calcification after 2 months of implantation. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Materials Science & Engineering C - Materials for Biological Applications | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Evaluation of calcification in porcine valves treated by ultraviolet ray and glutaraldehyde | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Hwal Suh | - |
dc.contributor.googleauthor | Jong-Cheol Park | - |
dc.identifier.doi | 10.1016/S0928-4931(00)00178-8 | - |
dc.contributor.localId | A01662 | - |
dc.relation.journalcode | J02186 | - |
dc.identifier.eissn | 0928-4931 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S0928493100001788 | - |
dc.subject.keyword | Porcine valve | - |
dc.subject.keyword | Glutaraldehyde | - |
dc.subject.keyword | Ultraviolet ray | - |
dc.subject.keyword | Calcification | - |
dc.subject.keyword | In vitro flow type | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | 박종철 | - |
dc.citation.volume | 13 | - |
dc.citation.number | 1~2 | - |
dc.citation.startPage | 65 | - |
dc.citation.endPage | 73 | - |
dc.identifier.bibliographicCitation | Materials Science & Engineering C - Materials for Biological Applications, Vol.13(1~2) : 65-73, 2000 | - |
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