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Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

 Kim J  ;  Yook JI O  ;  Park KK  ;  Jung SY  ;  Hong JC  ;  Kim KJ  ;  Kim JA  ;  Chung WY 
 Anticancer Research, Vol.20(3A) : 1493-1498, 2000 
Journal Title
 Anticancer Research 
Issue Date
9,10-Dimethyl-1,2-benzanthracene ; Animals ; Antimutagenic Agents/therapeutic use* ; Carcinogens/antagonists & inhibitors ; Cell Division ; Chlorophyllides/therapeutic use* ; Disease Models, Animal ; Female ; Mice ; Mice, Inbred ICR ; Ornithine Decarboxylase/genetics ; Ornithine Decarboxylase/metabolism ; Proto-Oncogene Proteins c-fos/genetics ; Proto-Oncogene Proteins c-fos/metabolism ; Proto-Oncogene Proteins c-jun/genetics ; Proto-Oncogene Proteins c-jun/metabolism ; RNA, Messenger/metabolism ; Skin Neoplasms/chemically induced ; Skin Neoplasms/metabolism ; Skin Neoplasms/pathology ; Skin Neoplasms/prevention & control* ; Tetradecanoylphorbol Acetate
This study aimed to elucidate the inhibitory effects of chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed. CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin(김진)
Park, Kwang Kyun(박광균)
Yook, Jong In(육종인) ORCID logo https://orcid.org/0000-0002-7318-6112
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
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