0 143

Cited 0 times in

Anti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis

DC Field Value Language
dc.contributor.author김진-
dc.contributor.author박광균-
dc.contributor.author육종인-
dc.contributor.author정원윤-
dc.contributor.author박광균-
dc.contributor.author육종인-
dc.contributor.author정원윤-
dc.date.accessioned2019-11-11T05:01:41Z-
dc.date.available2019-11-11T05:01:41Z-
dc.date.issued2000-
dc.identifier.issn0250-7005-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171552-
dc.description.abstractThis study aimed to elucidate the inhibitory effects of chlorophyllin (CHL) at different promotion stages in a DMBA-TPA-induced mouse skin carcinogenesis model. TPA promotion was undertaken for 6, 18 and 24 weeks, respectively. Proliferating activity was observed immunohistochemically and the ornithine decarboxylase (ODC) mRNA level was analyzed by reverse transcriptase-polymerase chain reaction. Messenger RNAs for c-fos, c-jun and jun-B were also observed. CHL treatment clearly reduced proliferating activity and the level of ODC mRNA at the 18-week-promotion stage. When promoted for 24 weeks, CHL was not effective in reducing proliferating activity and ODC mRNA expression. These results indicate that the promotion stage of each target tissue should be considered in a chemopreventive program.-
dc.description.statementOfResponsibilityprohibition-
dc.languageEnglish-
dc.publisherInternational Institute of Anticancer Research-
dc.relation.isPartOfAnticancer Research-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESH9,10-Dimethyl-1,2-benzanthracene-
dc.subject.MESHAnimals-
dc.subject.MESHAntimutagenic Agents/therapeutic use*-
dc.subject.MESHCarcinogens/antagonists & inhibitors-
dc.subject.MESHCell Division-
dc.subject.MESHChlorophyllides/therapeutic use*-
dc.subject.MESHDisease Models, Animal-
dc.subject.MESHFemale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred ICR-
dc.subject.MESHOrnithine Decarboxylase/genetics-
dc.subject.MESHOrnithine Decarboxylase/metabolism-
dc.subject.MESHProto-Oncogene Proteins c-fos/genetics-
dc.subject.MESHProto-Oncogene Proteins c-fos/metabolism-
dc.subject.MESHProto-Oncogene Proteins c-jun/genetics-
dc.subject.MESHProto-Oncogene Proteins c-jun/metabolism-
dc.subject.MESHRNA, Messenger/metabolism-
dc.subject.MESHSkin Neoplasms/chemically induced-
dc.subject.MESHSkin Neoplasms/metabolism-
dc.subject.MESHSkin Neoplasms/pathology-
dc.subject.MESHSkin Neoplasms/prevention & control*-
dc.subject.MESHTetradecanoylphorbol Acetate-
dc.titleAnti-promotion effect of chlorophyllin in DMBA-TPA-Induced mouse skin carcinogenesis-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Oral Pathology (구강병리학교실)-
dc.contributor.googleauthorKim J-
dc.contributor.googleauthorYook JI O-
dc.contributor.googleauthorPark KK-
dc.contributor.googleauthorJung SY-
dc.contributor.googleauthorHong JC-
dc.contributor.googleauthorKim KJ-
dc.contributor.googleauthorKim JA-
dc.contributor.googleauthorChung WY-
dc.contributor.localIdA01009-
dc.contributor.localIdA01429-
dc.contributor.localIdA01429-
dc.contributor.localIdA02536-
dc.contributor.localIdA02536-
dc.contributor.localIdA03676-
dc.contributor.localIdA03676-
dc.contributor.localIdA01429-
dc.contributor.localIdA01429-
dc.contributor.localIdA02536-
dc.contributor.localIdA02536-
dc.contributor.localIdA03676-
dc.contributor.localIdA03676-
dc.relation.journalcodeJ00188-
dc.identifier.eissn1791-7530-
dc.identifier.pmid10928061-
dc.contributor.alternativeNameKim, Jin-
dc.contributor.affiliatedAuthor김진-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor박광균-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor육종인-
dc.contributor.affiliatedAuthor정원윤-
dc.contributor.affiliatedAuthor정원윤-
dc.citation.volume20-
dc.citation.number3A-
dc.citation.startPage1493-
dc.citation.endPage1498-
dc.identifier.bibliographicCitationAnticancer Research, Vol.20(3A) : 1493-1498, 2000-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.