13 19

Cited 0 times in

Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation

Authors
 Yoorim Choi  ;  Dong Suk Yoon  ;  Kyoung-Mi Lee  ;  Seong Mi Choi  ;  Myon-Hee Lee  ;  Kwang Hwan Park  ;  Seung Hwan Han  ;  Jin Woo Lee 
Citation
 Aging and Disease, Vol.10(4) : 818-833, 2019 
Journal Title
 Aging and Disease 
Issue Date
2019
Keywords
Bone regeneration ; MSC therapy ; Mesenchymal stem cells ; Resveratrol ; Small molecule
Abstract
Mesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine. However, MSCs age rapidly during long-term ex vivo culture and lose their therapeutic potential before they reach effective cell doses (ECD) for cell therapy. Thus, a prerequisite for effective MSC therapy is the development of cell culture methods to preserve the therapeutic potential during long-term ex vivo cultivation. Resveratrol (RSV) has been highlighted as a therapeutic candidate for bone disease. Although RSV treatment has beneficial effects on bone-forming cells, in vivo studies are lacking. The current study showed that long-term (6 weeks from primary culture date)-cultured MSCs with RSV induction retained their proliferative and differentiation potential despite reaching ECD. The mechanism of RSV action depends entirely on the SIRT1-SOX2 axis in MSC culture. In a rat calvarial defect model, RSV induction significantly improved bone regeneration after MSC transplantation. This study demonstrated an example of efficient MSC therapy for treating bone defects by providing a new strategy using the plant polyphenol RSV.
Files in This Item:
T201903727.pdf Download
DOI
10.14336/AD.2018.0802
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Park, Kwang Hwan(박광환) ORCID logo https://orcid.org/0000-0002-2110-0559
Lee, Kyoung Mi(이경미) ORCID logo https://orcid.org/0000-0002-9038-8162
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
Han, Seung Hwan(한승환) ORCID logo https://orcid.org/0000-0002-7975-6067
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171496
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse