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Enhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation

DC FieldValueLanguage
dc.contributor.author박광환-
dc.contributor.author이진우-
dc.contributor.author한승환-
dc.contributor.author이경미-
dc.date.accessioned2019-10-28T02:07:12Z-
dc.date.available2019-10-28T02:07:12Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171496-
dc.description.abstractMesenchymal stem cells (MSCs) are an attractive cell source for regenerative medicine. However, MSCs age rapidly during long-term ex vivo culture and lose their therapeutic potential before they reach effective cell doses (ECD) for cell therapy. Thus, a prerequisite for effective MSC therapy is the development of cell culture methods to preserve the therapeutic potential during long-term ex vivo cultivation. Resveratrol (RSV) has been highlighted as a therapeutic candidate for bone disease. Although RSV treatment has beneficial effects on bone-forming cells, in vivo studies are lacking. The current study showed that long-term (6 weeks from primary culture date)-cultured MSCs with RSV induction retained their proliferative and differentiation potential despite reaching ECD. The mechanism of RSV action depends entirely on the SIRT1-SOX2 axis in MSC culture. In a rat calvarial defect model, RSV induction significantly improved bone regeneration after MSC transplantation. This study demonstrated an example of efficient MSC therapy for treating bone defects by providing a new strategy using the plant polyphenol RSV.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherJKL International-
dc.relation.isPartOfAging and Disease-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleEnhancement of Mesenchymal Stem Cell-Driven Bone Regeneration by Resveratrol-Mediated SOX2 Regulation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Orthopedic Surgery (정형외과학교실)-
dc.contributor.googleauthorYoorim Choi-
dc.contributor.googleauthorDong Suk Yoon-
dc.contributor.googleauthorKyoung-Mi Lee-
dc.contributor.googleauthorSeong Mi Choi-
dc.contributor.googleauthorMyon-Hee Lee-
dc.contributor.googleauthorKwang Hwan Park-
dc.contributor.googleauthorSeung Hwan Han-
dc.contributor.googleauthorJin Woo Lee-
dc.identifier.doi10.14336/AD.2018.0802-
dc.contributor.localIdA01437-
dc.contributor.localIdA03230-
dc.contributor.localIdA03230-
dc.contributor.localIdA04305-
dc.contributor.localIdA04305-
dc.contributor.localIdA04619-
dc.contributor.localIdA04619-
dc.relation.journalcodeJ02962-
dc.identifier.eissn2152-5250-
dc.identifier.pmid31440387-
dc.subject.keywordBone regeneration-
dc.subject.keywordMSC therapy-
dc.subject.keywordMesenchymal stem cells-
dc.subject.keywordResveratrol-
dc.subject.keywordSmall molecule-
dc.contributor.alternativeNamePark, Kwang Hwan-
dc.contributor.affiliatedAuthor박광환-
dc.contributor.affiliatedAuthor이진우-
dc.contributor.affiliatedAuthor이진우-
dc.contributor.affiliatedAuthor한승환-
dc.contributor.affiliatedAuthor한승환-
dc.contributor.affiliatedAuthor이경미-
dc.contributor.affiliatedAuthor이경미-
dc.citation.volume10-
dc.citation.number4-
dc.citation.startPage818-
dc.citation.endPage833-
dc.identifier.bibliographicCitationAging and Disease, Vol.10(4) : 818-833, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers

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