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Bone Regeneration Effect of Hyperbaric Oxygen Therapy Duration on Calvarial Defects in Irradiated Rats

 Kyeong-Mee Park  ;  Changdae Kim  ;  Wonse Park  ;  Young-Bum Park  ;  Moon-Kyu Chung  ;  Sungtae Kim 
 BioMed Research International, Vol.2019 : 9051713, 2019 
Journal Title
 BioMed Research International 
Issue Date
Animals ; Bone Regeneration/radiation effects* ; Hyperbaric Oxygenation* ; Male ; Radiation Injuries, Experimental*/diagnostic imaging ; Radiation Injuries, Experimental*/metabolism ; Radiation Injuries, Experimental*/pathology ; Radiation Injuries, Experimental*/therapy ; Rats ; Rats, Sprague-Dawley ; Skull*/diagnostic imaging ; Skull*/injuries ; Skull*/metabolism ; Skull*/pathology ; X-Ray Microtomography ; X-Rays/adverse effects*
Objective: In this study, we evaluated changes in bone remodeling in an irradiated rat calvarial defect model according to duration of hyperbaric oxygen therapy. Materials and Methods: The 28 rats were divided into four groups. Radiation of 12 Gy was applied to the skull, and 5-mm critical size defects were formed on both sides of the skull. Bone grafts were applied to one side of formed defects. From the day after surgery, HBO was applied for 0, 1, and 3 weeks. At 6 weeks after bone graft, experimental sites were removed and analyzed for radiography, histology, and histomorphometry. Results: Micro-CT analysis showed a significant increase in new bone volume in the HBO-3 group, with or without bone graft. When bone grafting was performed, BV, BS, and BS/TV all significantly increased. Histomorphometric analysis showed significant increases in %NBA and %BVN in the HBO-1 and HBO-3 groups, regardless of bone graft. Conclusion: Hyperbaric oxygen therapy was effective for bone regeneration with only 1 week of treatment.
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2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
Yonsei Authors
Park, Young Bum(박영범)
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Chung, Moon Kyu(정문규)
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