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Measurement of Multiple Solid Portions in Part-Solid Nodules for T Categorization: Evaluation of Prognostic Implication

Authors
 Hyungjin Kim  ;  Jin Mo Goo  ;  Young Joo Suh  ;  Eui Jin Hwang  ;  Chang Min Park  ;  Young Tae Kim 
Citation
 Journal of Thoracic Oncology, Vol.13(12) : 1864-1872, 2018 
Journal Title
 Journal of Thoracic Oncology 
ISSN
 1556-0864 
Issue Date
2018
MeSH
Adenocarcinoma of Lung/diagnostic imaging ; Adenocarcinoma of Lung/pathology* ; Adenocarcinoma of Lung/surgery ; Aged ; Carcinoma, Non-Small-Cell Lung/diagnostic imaging ; Carcinoma, Non-Small-Cell Lung/pathology* ; Carcinoma, Non-Small-Cell Lung/surgery ; Female ; Follow-Up Studies ; Humans ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology* ; Lung Neoplasms/surgery ; Male ; Middle Aged ; Neoplasm Recurrence, Local/diagnostic imaging ; Neoplasm Recurrence, Local/pathology* ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging ; Retrospective Studies ; Solitary Pulmonary Nodule/diagnostic imaging ; Solitary Pulmonary Nodule/pathology* ; Solitary Pulmonary Nodule/surgery ; Survival Rate ; Tomography, X-Ray Computed/methods
Keywords
Adenocarcinoma ; Multidetector computed tomography ; Neoplasm staging ; Part-solid nodule ; Solid portion
Abstract
INTRODUCTION: Our study aimed to analyze the prognostic implication of the multiplicity of solid portions in part-solid nodules (PSNs) on computed tomography scans and compare the prognostic performance of various measures of solid portions, including the single largest solid portion, solid proportion, and summated multiple solid portion measurements. METHODS: The cases of a total of 345 patients with surgically resected stage IA adenocarcinomas manifesting as PSNs were retrospectively reviewed. The multiplicity of the solid portion in PSNs was determined and the diameter of each solid portion was measured. The prognostic implication of the multiplicity of the solid portion and other clinical variables in relation to disease-free survival (DFS) was analyzed by using Cox regression. In addition, risk stratification based on the single largest solid portion, sum of the solid portions, single solid proportion, and sum of the solid proportions was conducted. Next, concordance indices (C-indices) for DFS were obtained for each measure and compared. Intrareader and interreader measurement variability was assessed. RESULTS: Multiplicity of the solid portion did not have a significant effect on DFS; clinical T category was the only independent risk factor for tumor recurrence (p < 0.05). The C-index of the single solid portion (conventional clinical T category) was 0.817 (95% confidence interval: 0.691-0.942). There were no significant differences (p > 0.05) between the C-indices of the single solid portion and other solid portion measures. Interreader measurement variability was substantial. CONCLUSIONS: The current clinical T categorization of PSNs based on the single solid portion measurement is appropriate.
Full Text
https://www.sciencedirect.com/science/article/pii/S1556086418331757
DOI
10.1016/j.jtho.2018.09.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Suh, Young Joo(서영주) ORCID logo https://orcid.org/0000-0002-2078-5832
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171223
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