Background: Sebaceous neoplasm is a rare subgroup of appendageal
tumors that differentiate towards sebaceous adnexal
structures of the skin and are known to be associated
with visceral malignancy. Objective: We aimed to analyze
and compare the clinical data including the past history of associated
visceral malignancy in patients with sebaceous carcinoma
(SC) and benign sebaceous neoplasms (BSN), such as
sebaceous adenomas and sebaceomas. Methods: We retrospectively
reviewed the cases of consecutive patients diagnosed
with sebaceous neoplasms. Basic demographic data,
past medical history, and clinical data regarding the size, location,
and presence of associated visceral malignancies
were evaluated. Results: A total of 80 patients of sebaceous
neoplasms (51 SC, 29 BSN) were included. A total of 18 associated
visceral malignancies were found in 14 patients (8 SC,
6 BSN). Two patients were diagnosed with subsequent visceral
malignancies during the primary work-up process for
sebaceous neoplasms. The mean age at diagnosis of the visceral
malignancies was 63.9 and 47.5 years for patients with
SC and BSN, respectively. The most common site of visceral
malignancies was the gastrointestinal (GI) tract. Adenocarcinoma
was the most common histologic type of the visceral
malignancy noted. Conclusion: We observed associated visceral
malignancies in 15.7% of patients with SC and 20.7%
with BSN. Our results suggest a need for screening of visceral
malignancies, especially of the GI tract, in patients with sebaceous
neoplasms.