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Clinical Features and Association with Visceral Malignancy in 80 Patients with Sebaceous Neopla는

 Jee Eun Kim  ;  Jong Hoon Kim  ;  Kee-Yang Chung  ;  Jin Sook Yoon  ;  Mi Ryung Roh 
 Annals of Dermatology, Vol.31(1) : 14-21, 2019 
Journal Title
 Annals of Dermatology 
Issue Date
Sebaceoma ; Sebaceous adenoma ; Sebaceous carcinoma ; Visceral malignancy
Background: Sebaceous neoplasm is a rare subgroup of appendageal tumors that differentiate towards sebaceous adnexal structures of the skin and are known to be associated with visceral malignancy. Objective: We aimed to analyze and compare the clinical data including the past history of associated visceral malignancy in patients with sebaceous carcinoma (SC) and benign sebaceous neoplasms (BSN), such as sebaceous adenomas and sebaceomas. Methods: We retrospectively reviewed the cases of consecutive patients diagnosed with sebaceous neoplasms. Basic demographic data, past medical history, and clinical data regarding the size, location, and presence of associated visceral malignancies were evaluated. Results: A total of 80 patients of sebaceous neoplasms (51 SC, 29 BSN) were included. A total of 18 associated visceral malignancies were found in 14 patients (8 SC, 6 BSN). Two patients were diagnosed with subsequent visceral malignancies during the primary work-up process for sebaceous neoplasms. The mean age at diagnosis of the visceral malignancies was 63.9 and 47.5 years for patients with SC and BSN, respectively. The most common site of visceral malignancies was the gastrointestinal (GI) tract. Adenocarcinoma was the most common histologic type of the visceral malignancy noted. Conclusion: We observed associated visceral malignancies in 15.7% of patients with SC and 20.7% with BSN. Our results suggest a need for screening of visceral malignancies, especially of the GI tract, in patients with sebaceous neoplasms.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Hoon(김종훈) ORCID logo https://orcid.org/0000-0002-3385-8180
Kim, Jee Eun(김지언) ORCID logo https://orcid.org/0000-0003-0795-5742
Roh, Mi Ryung(노미령) ORCID logo https://orcid.org/0000-0002-6285-2490
Yoon, Jin Sook(윤진숙) ORCID logo https://orcid.org/0000-0002-8751-9467
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
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