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Sirtuin3 Protected Against Neuronal Damage and Cycled into Nucleus in Status Epilepticus Model

Authors
 Inja Cho  ;  Kyoung Hoon Jeong  ;  Jing Zhu  ;  Yun Ho Choi  ;  Kyoo Ho Cho  ;  Kyoung Heo  ;  Won-Joo Kim 
Citation
 Molecular Neurobiology, Vol.56(7) : 4894-4903, 2019 
Journal Title
 Molecular Neurobiology 
ISSN
 0893-7648 
Issue Date
2019
Keywords
Manganese superoxide dismutase ; Mitochondria ; Nucleus ; Sirtuin3 ; Status epilepticus
Abstract
In pathological conditions such as status epilepticus (SE), neuronal cell death can occur due to oxidative stress that is caused by an excessive production and accumulation of reactive oxygen species (ROS). Sirtuin3 (Sirt3) plays an important role in maintaining appropriate ROS levels by regulating manganese superoxide dismutase (MnSOD), which scavenges ROS in mitochondria. Using a SE model, we demonstrated that Sirt3 directly regulated MnSOD activity by deacetylation, which protects hippocampal cells against damage from ROS. Furthermore, we showed that after formation in the nucleus, Sirt3 is primarily located in the mitochondria, where it is activated and exerts its major function. Sirt3 then completed its pathway and moved back into the nucleus. Our data indicate that Sirt3 has an important function in regulating MnSOD, which results in decreased ROS in hippocampal cells. Sirt3 may have potential as an effective therapeutic target in SE conditions that would delay the progression of epileptogenesis.
Full Text
https://link.springer.com/article/10.1007%2Fs12035-018-1399-8
DOI
10.1007/s12035-018-1399-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Joo(김원주) ORCID logo https://orcid.org/0000-0002-5850-010X
Cho, Kyoo Ho(조규호) ORCID logo https://orcid.org/0000-0003-2402-7198
Cho, Inja(조인자)
Heo, Kyoung(허경)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171135
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