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Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma

Authors
 Seung Hwa Son  ;  Won-Yoon Chung 
Citation
 International Journal of Oral Biology, Vol.44(2) : 37-42, 2019 
Journal Title
 International Journal of Oral Biology 
ISSN
 1226-7155 
Issue Date
2019
Keywords
Role of proteases ; cytokines ; and growth factors in bone invasion by oral squamous cell carcinoma
Abstract
Oral squamous cell carcinoma (OSCC) is the most common oral malignancy and an increasing global public health problem. OSCC frequently invades the jaw bone. OSCC-induced bone invasion has a significant impact on tumor stage, treatment selection, patient outcome, and quality of life. A number of studies have shown that osteoclast-mediated bone resorption is a major step in the progression of bone invasion by OSCC; however, the molecular mechanisms involved in OSCC bone invasion are not yet clear. In this review, we present the clinical types of OSCC bone invasion and summarize the role of key molecules, including proteases, cytokines, and growth factors, in the sequential process of bone invasion. A better understanding of bone invasion will facilitate the discovery of molecular targets for early detection and treatment of OSCC bone invasion.
Files in This Item:
T201902911.pdf Download
DOI
10.11620/IJOB.2019.44.2.37
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Chung, Won Yoon(정원윤) ORCID logo https://orcid.org/0000-0001-8428-9005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171106
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