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Bioactive resin-based composite with surface pre-reacted glass-ionomer filler and zwitterionic material to prevent the formation of multi-species biofilm

Authors
 Myung-Jin Lee  ;  Jae-Sung Kwon  ;  Ji-Yeong Kim  ;  Jeong-Hyun Ryu  ;  Ji-Young Seo  ;  Sungil Jang  ;  Kwang-Mahn Kim  ;  Chung-Ju Hwang  ;  Sung-Hwan Choi 
Citation
 Dental Materials, Vol.35(9) : 1331-1341, 2019 
Journal Title
 Dental Materials 
ISSN
 0109-5641 
Issue Date
2019
Keywords
Antibacterial activity ; Bacterial adhesion ; Bioactivity ; Multispecies biofilm growth ; Oral bacteria ; Protein adsorption ; Resin-based composite ; Surface pre-reacted glass ionomer ; Zwitterion
Abstract
OBJECTIVE: This study evaluated the synergetic effect between surface pre-reacted glass-ionomer (SPRG) filler and 2-methacryloyloxyethyl phosphorylcholine (MPC), for inhibiting multi-species biofilm formation, while maintaining or even improving the original beneficial features of SPRG-filled resin-based composite (RBC). METHODS: MPC (1.5-10wt%) was incorporated into commercial SPRG-filled RBC. Then, the inherent properties of RBC, and ion release and acid-neutralising properties associated with SPRG were investigated. Further, protein adsorptions and bacterial adhesion and viability on the SPRG-filled RBC surfaces were studied using four kinds of oral bacteria; Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, and Porphyromonas gingivalis. Finally, the thickness and biomass of the human saliva-derived biofilm model cultured on test and control samples were analysed. RESULTS: Addition of MPC content resulted in decreased flexural strength and wettability of SPRG-filled RBC. SPRG-filled RBC released significantly higher amounts of multiple ions as contents of MPC increased. Meanwhile, SPRG-filled RBC with 5-wt% MPC significantly improved acid-neutralising properties than those of other test and control samples (P<0.001). SPRG-filled RBC with 3wt% MPC significantly reduced the amount of adsorbed bovine serum albumin and proteins from the brain heart infusion medium as compared to the control (P<0.01). A similar trend was observed in the attachment of four types of bacteria and multi-species biofilm (P<0.01). SIGNIFICANCE: Despite limitation in terms of deteriorations of some physical properties, addition of 3% MPC to SPRG-filled RBC leads to inhibition of the attachment of multi-species bacteria on its surface, as well as inhibition of biofilm growth. Moreover, the original important bioactive features of SPRG-filled RBC such as ion release and acid neutralisations are either maintained or improved upon adding MPC.
Full Text
https://www.sciencedirect.com/science/article/pii/S0109564119302118
DOI
10.1016/j.dental.2019.06.004
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Lee, Myung-Jin(이명진)
Choi, Sung Hwan(최성환) ORCID logo https://orcid.org/0000-0002-1150-0268
Hwang, Chung Ju(황충주) ORCID logo https://orcid.org/0000-0003-3024-4551
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/171100
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