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Bioactive resin-based composite with surface pre-reacted glass-ionomer filler and zwitterionic material to prevent the formation of multi-species biofilm

DC FieldValueLanguage
dc.contributor.author권재성-
dc.contributor.author김광만-
dc.contributor.author최성환-
dc.contributor.author황충주-
dc.contributor.author이명진-
dc.date.accessioned2019-09-20T07:53:06Z-
dc.date.available2019-09-20T07:53:06Z-
dc.date.issued2019-
dc.identifier.issn0109-5641-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/171100-
dc.description.abstractOBJECTIVE: This study evaluated the synergetic effect between surface pre-reacted glass-ionomer (SPRG) filler and 2-methacryloyloxyethyl phosphorylcholine (MPC), for inhibiting multi-species biofilm formation, while maintaining or even improving the original beneficial features of SPRG-filled resin-based composite (RBC). METHODS: MPC (1.5-10wt%) was incorporated into commercial SPRG-filled RBC. Then, the inherent properties of RBC, and ion release and acid-neutralising properties associated with SPRG were investigated. Further, protein adsorptions and bacterial adhesion and viability on the SPRG-filled RBC surfaces were studied using four kinds of oral bacteria; Streptococcus mutans, Actinomyces naeslundii, Veillonella parvula, and Porphyromonas gingivalis. Finally, the thickness and biomass of the human saliva-derived biofilm model cultured on test and control samples were analysed. RESULTS: Addition of MPC content resulted in decreased flexural strength and wettability of SPRG-filled RBC. SPRG-filled RBC released significantly higher amounts of multiple ions as contents of MPC increased. Meanwhile, SPRG-filled RBC with 5-wt% MPC significantly improved acid-neutralising properties than those of other test and control samples (P<0.001). SPRG-filled RBC with 3wt% MPC significantly reduced the amount of adsorbed bovine serum albumin and proteins from the brain heart infusion medium as compared to the control (P<0.01). A similar trend was observed in the attachment of four types of bacteria and multi-species biofilm (P<0.01). SIGNIFICANCE: Despite limitation in terms of deteriorations of some physical properties, addition of 3% MPC to SPRG-filled RBC leads to inhibition of the attachment of multi-species bacteria on its surface, as well as inhibition of biofilm growth. Moreover, the original important bioactive features of SPRG-filled RBC such as ion release and acid neutralisations are either maintained or improved upon adding MPC.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Science-
dc.relation.isPartOfDental Materials-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBioactive resin-based composite with surface pre-reacted glass-ionomer filler and zwitterionic material to prevent the formation of multi-species biofilm-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorMyung-Jin Lee-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorJi-Yeong Kim-
dc.contributor.googleauthorJeong-Hyun Ryu-
dc.contributor.googleauthorJi-Young Seo-
dc.contributor.googleauthorSungil Jang-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorChung-Ju Hwang-
dc.contributor.googleauthorSung-Hwan Choi-
dc.identifier.doi10.1016/j.dental.2019.06.004-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.contributor.localIdA00312-
dc.contributor.localIdA04083-
dc.contributor.localIdA04083-
dc.contributor.localIdA04492-
dc.contributor.localIdA04492-
dc.relation.journalcodeJ00699-
dc.identifier.eissn1879-0097-
dc.identifier.pmid31320183-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0109564119302118-
dc.subject.keywordAntibacterial activity-
dc.subject.keywordBacterial adhesion-
dc.subject.keywordBioactivity-
dc.subject.keywordMultispecies biofilm growth-
dc.subject.keywordOral bacteria-
dc.subject.keywordProtein adsorption-
dc.subject.keywordResin-based composite-
dc.subject.keywordSurface pre-reacted glass ionomer-
dc.subject.keywordZwitterion-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor황충주-
dc.contributor.affiliatedAuthor황충주-
dc.citation.volume35-
dc.citation.number9-
dc.citation.startPage1331-
dc.citation.endPage1341-
dc.identifier.bibliographicCitationDental Materials, Vol.35(9) : 1331-1341, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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