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Lipidomic profiles disturbed by the internet gaming disorder in young Korean males

Authors
 Chang-Wan Lee  ;  Deokjong Lee  ;  Eun Mi Lee  ;  Soo Jin Park  ;  Dong Yoon Ji  ;  Do Yup Lee  ;  Young-Chul Jung 
Citation
 Journal of Chromatography B, Vol.1114~1115 : 119-124, 2019 
Journal Title
 Journal of Chromatography B 
ISSN
 1570-0232 
Issue Date
2019
MeSH
Adult ; Behavior, Addictive/blood* ; Behavior, Addictive/metabolism* ; Chromatography, High Pressure Liquid/methods* ; Humans ; Lipids/blood* ; Lysophosphatidylcholines/blood ; Male ; Mass Spectrometry ; Metabolomics ; Republic of Korea ; Video Games* ; Young Adult
Abstract
Internet Gaming Disorder (IGD) is characterized by uncontrollable and persistent playing of internet games despite the occurrence of negative consequences. Although there is a worldwide treatment demand, IGD still doesn't have an explicit biomarker. The primary goal of the study is to characterize lipidomic profiles specific to internet gaming disorder (IGD) based on liquid-chromatography Orbitrap mass-spectrometry (LC Orbitrap MS). Primarily, a total of 19 lipids were significantly dys-regulated in the IGD group compared to healthy controls. The lipidomic feature was mainly characterized by various types of phosphatidylcholines (PCs) and lyso-phosphatidylcholines (LysoPCs). Subsequent multivariate statistical model and linear regression model prioritized two LysoPCs (C16:0 and C18:0) for potential biomarker. Receiver operating characteristic (ROC) analysis demonstrated excellent performance of the combined lipid set for discriminating the IGD group from healthy controls (AUC: 0.981, 95% confidence interval: 0.958-1.000). Additional evaluation with potential confounders and clinical parameters suggested robustness and potential applicability of the outcome as biomarkers which may aid diagnosis.
Full Text
https://www.sciencedirect.com/science/article/pii/S1570023218316040
DOI
10.1016/j.jchromb.2019.03.027
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Deokjong(이덕종) ORCID logo https://orcid.org/0000-0002-5425-4677
Jung, Young Chul(정영철) ORCID logo https://orcid.org/0000-0002-0578-2510
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170966
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