Cited 3 times in
Lipidomic profiles disturbed by the internet gaming disorder in young Korean males
DC Field | Value | Language |
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dc.contributor.author | 정영철 | - |
dc.contributor.author | 이덕종 | - |
dc.date.accessioned | 2019-09-20T07:35:37Z | - |
dc.date.available | 2019-09-20T07:35:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 1570-0232 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/170966 | - |
dc.description.abstract | Internet Gaming Disorder (IGD) is characterized by uncontrollable and persistent playing of internet games despite the occurrence of negative consequences. Although there is a worldwide treatment demand, IGD still doesn't have an explicit biomarker. The primary goal of the study is to characterize lipidomic profiles specific to internet gaming disorder (IGD) based on liquid-chromatography Orbitrap mass-spectrometry (LC Orbitrap MS). Primarily, a total of 19 lipids were significantly dys-regulated in the IGD group compared to healthy controls. The lipidomic feature was mainly characterized by various types of phosphatidylcholines (PCs) and lyso-phosphatidylcholines (LysoPCs). Subsequent multivariate statistical model and linear regression model prioritized two LysoPCs (C16:0 and C18:0) for potential biomarker. Receiver operating characteristic (ROC) analysis demonstrated excellent performance of the combined lipid set for discriminating the IGD group from healthy controls (AUC: 0.981, 95% confidence interval: 0.958-1.000). Additional evaluation with potential confounders and clinical parameters suggested robustness and potential applicability of the outcome as biomarkers which may aid diagnosis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | Journal of Chromatography B | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Behavior, Addictive/blood* | - |
dc.subject.MESH | Behavior, Addictive/metabolism* | - |
dc.subject.MESH | Chromatography, High Pressure Liquid/methods* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Lipids/blood* | - |
dc.subject.MESH | Lysophosphatidylcholines/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mass Spectrometry | - |
dc.subject.MESH | Metabolomics | - |
dc.subject.MESH | Republic of Korea | - |
dc.subject.MESH | Video Games* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Lipidomic profiles disturbed by the internet gaming disorder in young Korean males | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Psychiatry (정신과학교실) | - |
dc.contributor.googleauthor | Chang-Wan Lee | - |
dc.contributor.googleauthor | Deokjong Lee | - |
dc.contributor.googleauthor | Eun Mi Lee | - |
dc.contributor.googleauthor | Soo Jin Park | - |
dc.contributor.googleauthor | Dong Yoon Ji | - |
dc.contributor.googleauthor | Do Yup Lee | - |
dc.contributor.googleauthor | Young-Chul Jung | - |
dc.identifier.doi | 10.1016/j.jchromb.2019.03.027 | - |
dc.contributor.localId | A03656 | - |
dc.relation.journalcode | J01314 | - |
dc.identifier.eissn | 1873-376X | - |
dc.identifier.pmid | 30951964 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1570023218316040 | - |
dc.contributor.alternativeName | Jung, Young Chul | - |
dc.contributor.affiliatedAuthor | 정영철 | - |
dc.citation.volume | 1114~1115 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 124 | - |
dc.identifier.bibliographicCitation | Journal of Chromatography B, Vol.1114~1115 : 119-124, 2019 | - |
dc.identifier.rimsid | 64198 | - |
dc.type.rims | ART | - |
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