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Body Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus

DC FieldValueLanguage
dc.contributor.author김영대-
dc.contributor.author남효석-
dc.contributor.author박형종-
dc.contributor.author이형우-
dc.contributor.author이혜선-
dc.contributor.author허지회-
dc.date.accessioned2019-09-20T07:26:54Z-
dc.date.available2019-09-20T07:26:54Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170903-
dc.description.abstractBackground: Overweight contributes to type 2 diabetes mellitus (T2DM) development. Although the obesity paradox has been suggested in many vascular diseases, little information is available about stroke patients with T2DM. We investigated whether body mass index (BMI) has a differential impact on the incidence of major adverse cardiovascular events (MACE) in patients with ischemic stroke and T2DM. Methods: This retrospective study used a prospective cohort of patients with acute ischemic stroke and included consecutive patients with T2DM after excluding those with active cancer or who died within 1 month of an index stroke. We investigated the long-term risk of MACE (stroke, myocardial infarction, unstable angina, coronary revascularization procedure, and death) according to BMI. Results: Among the 1,338 patients, MACE occurred in 415 patients (31.1%) during a median follow-up of 3.6 years. Compared to the normal weight group, MACE occurred more frequently in the underweight group [adjusted hazard ratio (HR) 1.55, 95% confidence interval (CI): 1.01-2.38], but less frequently in the overweight group (adjusted HR: 0.87, 95% CI: 0.70-1.08) and obese group (adjusted HR: 0.58, 95% CI: 0.41-0.86) group. In analyses of association between BMI and each component of MACE, stroke and cardiovascular mortality indicated an L- and a U-shaped pattern, respectively. However, fatal or non-fatal stroke showed an inverse pattern, and fatal or non-fatal cardiovascular events showed a reversed J-shaped pattern. Discussions: This study showed the overall presence of the obesity paradox in stroke patients with T2DM. However, obese patients had different risks of cardiovascular events and stroke.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherFrontiers Research Foundation-
dc.relation.isPartOfFrontiers in Neurology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleBody Mass Index and Prognosis in Ischemic Stroke Patients With Type 2 Diabetes Mellitus-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorHyungjong Park-
dc.contributor.googleauthorHyung Woo Lee-
dc.contributor.googleauthorJoonsang Yoo-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorHyo Suk Nam-
dc.contributor.googleauthorYoung Dae Kim-
dc.contributor.googleauthorJi Hoe Heo-
dc.identifier.doi10.3389/fneur.2019.00563-
dc.contributor.localIdA00702-
dc.contributor.localIdA01273-
dc.contributor.localIdA01273-
dc.contributor.localIdA05600-
dc.contributor.localIdA05600-
dc.contributor.localIdA05394-
dc.contributor.localIdA05394-
dc.contributor.localIdA03312-
dc.contributor.localIdA03312-
dc.contributor.localIdA04369-
dc.contributor.localIdA04369-
dc.relation.journalcodeJ02996-
dc.identifier.eissn1664-2295-
dc.identifier.pmid31231300-
dc.subject.keywordbody mass index-
dc.subject.keyworddiabetes mellitus-
dc.subject.keywordischemic stroke-
dc.subject.keywordmajor adverse cardiac event-
dc.subject.keywordmortality-
dc.subject.keywordobesity-
dc.contributor.alternativeNameKim, Young Dae-
dc.contributor.affiliatedAuthor김영대-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor남효석-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor박형종-
dc.contributor.affiliatedAuthor이형우-
dc.contributor.affiliatedAuthor이형우-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor이혜선-
dc.contributor.affiliatedAuthor허지회-
dc.contributor.affiliatedAuthor허지회-
dc.citation.volume10-
dc.citation.startPage563-
dc.identifier.bibliographicCitationFrontiers in Neurology, Vol.10 : 563, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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