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Radiomics on Gadoxetic Acid-Enhanced Magnetic Resonance Imaging for Prediction of Postoperative Early and Late Recurrence of Single Hepatocellular Carcinoma

Authors
 Sungwon Kim  ;  Jaeseung Shin  ;  Do-Young Kim  ;  Gi Hong Choi  ;  Myeong-Jin Kim  ;  and Jin-Young Choi 
Citation
 CLINICAL CANCER RESEARCH, Vol.25(13) : 3847-3855, 2019 
Journal Title
 CLINICAL CANCER RESEARCH 
ISSN
 1078-0432 
Issue Date
2019
Keywords
Anticuerpo anticitoplasma de neutrófilos ; Anticuerpo antifosfolípido ; Antineutrophil cytoplasmic antibody ; Antiphospholipid antibody ; Thrombosis ; Trombosis ; Vasculitis
Abstract
PURPOSE: To evaluate the usefulness of the radiomic model in predicting early (≤2 years) and late (>2 years) recurrence after curative resection in cases involving a single hepatocellular carcinoma (HCC) 2-5 cm in diameter using preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI), in comparison with the clinicopathologic model. EXPERIMENTAL DESIGN: This retrospective study included 167 patients with surgically resected and pathologically confirmed single HCC 2-5 cm in diameter (n = 167, training set:validation set = 128:39) who underwent preoperative gadoxetic acid-enhanced MRI between January 2010 and December 2015. A radiomic model, a clinicopathologic model, and a combined clinicopathologic-radiomic (CCR) model were built using a random survival forest to predict disease-free survival (DFS) in the following conditions: early DFS versus late DFS, dynamic phases, and the peritumoral area included in the segmentation. RESULTS: The radiomic model showed a prognostic performance comparable with the clinicopathologic model only with 3-mm peritumoral border extension [c-index difference (radiomic-clinicopathologic), -0.021, P = 0.758]. The CCR model with the 3-mm border extension showed the highest c-index value but no statistically significant improvement over the clinicopathologic model [CCR, 0.716 (0.627-0.799); clinicopathologic model, 0.696 (0.557-0.799)]. CONCLUSIONS: The prognostic value of the preoperative radiomic model with 3-mm border extension showed comparable performance with that of the postoperative clinicopathologic model for predicting DFS of early recurrence of HCC using gadoxetic acid-enhanced MRI. This suggests the importance of including peritumoral changes in the radiomic analysis of HCC.
Full Text
http://clincancerres.aacrjournals.org/content/25/13/3847.long
Files in This Item:
T201902393.pdf Download
DOI
10.1158/1078-0432.CCR-18-2861
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Kim, Sungwon(김성원) ORCID logo https://orcid.org/0000-0001-5455-6926
Shin, Jaeseung(신재승) ORCID logo https://orcid.org/0000-0002-6755-4732
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170463
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