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Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease

Authors
 Seok Jong Chung  ;  Yeong-Hun Park  ;  Han Soo Yoo  ;  Yang Hyun Lee  ;  Byoung Seok Yea  ;  Young H. Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.78 : 168-177, 2019 
Journal Title
 NEUROBIOLOGY OF AGING 
ISSN
 0197-4580 
Issue Date
2019
MeSH
Aged ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Cognition ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/pathology ; Cognitive Dysfunction/psychology ; Disease Progression ; Executive Function ; Female ; Humans ; Male ; Middle Aged ; Neuroimaging ; Neuropsychological Tests ; Parkinson Disease/complications ; Parkinson Disease/diagnostic imaging ; Parkinson Disease/pathology ; Parkinson Disease/psychology ; Prognosis ; Risk
Keywords
Mild cognitive impairment ; Parkinson's disease dementia ; Reverter
Abstract
This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's disease with mild cognitiveimpairment (PD-MCI). We recruited 217 patients with PD-MCI who underwent serial neuropsychological assessments 3-5 times (mean interval, 1.84 years). Thirty-six patients reverted to CogN (reverters) during follow-up, whereas the other 181 did not (nonreverters). We assessed the risk of cognitive worsening in PD-MCI reverters, nonreverters, and patients with PD-CogN (n = 88). In addition, we performed comparative analyses of comprehensive neuroimaging studies between the PD-MCI reverter (n = 17) and nonreverter (n = 34) subgroups. PD-MCI reverters had a lower risk of dementia conversion than nonreverters. In addition, PD-MCI reverters had similar risks of cognitive worsening with patients with PD-CogN. PD-MCI reverters exhibited greater cortical thickness in the right parahippocampal gyrus and less severely decreased functional connectivity in the default mode and executive control networks relative to nonreverters. Our results suggest that PD-MCI reverters have relatively preserved structural and functional integrity and a favorable cognitive prognosiscompared with nonreverters.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458019300739
DOI
10.1016/j.neurobiolaging.2019.02.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170390
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