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Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease

Authors
 Seok Jong Chung  ;  Yeong-Hun Park  ;  Han Soo Yoo  ;  Yang Hyun Lee  ;  Byoung Seok Yea  ;  Young H. Sohn  ;  Jong-Min Lee  ;  Phil Hyu Lee 
Citation
 NEUROBIOLOGY OF AGING, Vol.78 : 168-177, 2019 
Journal Title
NEUROBIOLOGY OF AGING
ISSN
 0197-4580 
Issue Date
2019
MeSH
Aged ; Cerebral Cortex/diagnostic imaging ; Cerebral Cortex/pathology ; Cerebral Cortex/physiopathology ; Cognition ; CognitiveDysfunction/complications ; CognitiveDysfunction/diagnostic imaging ; CognitiveDysfunction/pathology ; CognitiveDysfunction/psychology ; DiseaseProgression ; Executive Function ; Female ; Humans ; Male ; Middle Aged ; Neuroimaging ; Neuropsychological Tests ; ParkinsonDisease/complications ; ParkinsonDisease/diagnostic imaging ; ParkinsonDisease/pathology ; ParkinsonDisease/psychology ; Prognosis ; Risk
Keywords
Mildcognitiveimpairment ; Parkinson'sdiseasedementia ; Reverter
Abstract
This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to afavorablecognitiveprognosisin Parkinson'sdiseasewithmildcognitiveimpairment(PD-MCI). We recruited 217 patients with PD-MCI who underwent serial neuropsychological assessments 3-5 times (mean interval, 1.84years). Thirty-six patients reverted to CogN (reverters) during follow-up, whereas the other 181 did not (nonreverters). We assessed the risk ofcognitiveworsening in PD-MCIreverters, nonreverters, and patients with PD-CogN (n= 88). In addition, we performed comparative analyses of comprehensive neuroimaging studies between the PD-MCI reverter (n= 17) and nonreverter (n= 34) subgroups. PD-MCIrevertershad a lower risk of dementia conversion than nonreverters. In addition, PD-MCIrevertershad similar risks ofcognitiveworsening with patients with PD-CogN. PD-MCIrevertersexhibited greatercorticalthickness in the right parahippocampal gyrus and less severely decreased functional connectivity in the default mode and executive control networks relative to nonreverters. Our results suggest that PD-MCIrevertershave relatively preserved structural and functionalintegrityand afavorablecognitiveprognosiscompared with nonreverters.
Full Text
https://www.sciencedirect.com/science/article/pii/S0197458019300739
DOI
10.1016/j.neurobiolaging.2019.02.023
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Ye, Byoung Seok(예병석) ORCID logo https://orcid.org/0000-0003-0187-8440
Yoo, Han Soo(유한수) ORCID logo https://orcid.org/0000-0001-7846-6271
Lee, Yang Hyun(이양현)
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
Chung, Seok Jong(정석종) ORCID logo https://orcid.org/0000-0001-6086-3199
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170390
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