0 173

Cited 1 times in

Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease

DC FieldValueLanguage
dc.contributor.author손영호-
dc.contributor.author예병석-
dc.contributor.author유한수-
dc.contributor.author이양현-
dc.contributor.author이필휴-
dc.contributor.author정석종-
dc.date.accessioned2019-07-23T06:56:55Z-
dc.date.available2019-07-23T06:56:55Z-
dc.date.issued2019-
dc.identifier.issn0197-4580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170390-
dc.description.abstractThis study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's disease with mild cognitiveimpairment (PD-MCI). We recruited 217 patients with PD-MCI who underwent serial neuropsychological assessments 3-5 times (mean interval, 1.84 years). Thirty-six patients reverted to CogN (reverters) during follow-up, whereas the other 181 did not (nonreverters). We assessed the risk of cognitive worsening in PD-MCI reverters, nonreverters, and patients with PD-CogN (n = 88). In addition, we performed comparative analyses of comprehensive neuroimaging studies between the PD-MCI reverter (n = 17) and nonreverter (n = 34) subgroups. PD-MCI reverters had a lower risk of dementia conversion than nonreverters. In addition, PD-MCI reverters had similar risks of cognitive worsening with patients with PD-CogN. PD-MCI reverters exhibited greater cortical thickness in the right parahippocampal gyrus and less severely decreased functional connectivity in the default mode and executive control networks relative to nonreverters. Our results suggest that PD-MCI reverters have relatively preserved structural and functional integrity and a favorable cognitive prognosiscompared with nonreverters.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfNEUROBIOLOGY OF AGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCerebral Cortex/diagnostic imaging-
dc.subject.MESHCerebral Cortex/pathology-
dc.subject.MESHCerebral Cortex/physiopathology-
dc.subject.MESHCognition-
dc.subject.MESHCognitive Dysfunction/complications-
dc.subject.MESHCognitive Dysfunction/diagnostic imaging-
dc.subject.MESHCognitive Dysfunction/pathology-
dc.subject.MESHCognitive Dysfunction/psychology-
dc.subject.MESHDisease Progression-
dc.subject.MESHExecutive Function-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeuroimaging-
dc.subject.MESHNeuropsychological Tests-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/diagnostic imaging-
dc.subject.MESHParkinson Disease/pathology-
dc.subject.MESHParkinson Disease/psychology-
dc.subject.MESHPrognosis-
dc.subject.MESHRisk-
dc.titleMild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Neurology (신경과학교실)-
dc.contributor.googleauthorSeok Jong Chung-
dc.contributor.googleauthorYeong-Hun Park-
dc.contributor.googleauthorHan Soo Yoo-
dc.contributor.googleauthorYang Hyun Lee-
dc.contributor.googleauthorByoung Seok Yea-
dc.contributor.googleauthorYoung H. Sohn-
dc.contributor.googleauthorJong-Min Lee-
dc.contributor.googleauthorPhil Hyu Lee-
dc.identifier.doi10.1016/j.neurobiolaging.2019.02.023-
dc.contributor.localIdA01982-
dc.contributor.localIdA04603-
dc.contributor.localIdA04603-
dc.contributor.localIdA05367-
dc.contributor.localIdA05367-
dc.contributor.localIdA05714-
dc.contributor.localIdA05714-
dc.contributor.localIdA03270-
dc.contributor.localIdA03270-
dc.contributor.localIdA04666-
dc.contributor.localIdA04666-
dc.relation.journalcodeJ02322-
dc.identifier.eissn1558-1497-
dc.identifier.pmid30947112-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0197458019300739-
dc.subject.keywordMild cognitive impairment-
dc.subject.keywordParkinson's disease dementia-
dc.subject.keywordReverter-
dc.contributor.alternativeNameSohn, Young Ho-
dc.contributor.affiliatedAuthor손영호-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor예병석-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor유한수-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이양현-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor이필휴-
dc.contributor.affiliatedAuthor정석종-
dc.contributor.affiliatedAuthor정석종-
dc.citation.volume78-
dc.citation.startPage168-
dc.citation.endPage177-
dc.identifier.bibliographicCitationNEUROBIOLOGY OF AGING, Vol.78 : 168-177, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.