0 67

Cited 1 times in

Synergistic effect of hyperbaric oxygen therapy with PTH [1-34] on calvarial bone graft in irradiated rat

 Kyeong‐Mee Park  ;  Kyung‐Seok Hu  ;  Hyunmin Choi  ;  Seo‐Eun Oh  ;  Hyeong‐Il Kim  ;  Wonse Park  ;  Sungtae Kim 
 ORAL DISEASES, Vol.25(3) : 822-830, 2019 
Journal Title
Issue Date
animal model ;  bone graft ;  bone regeneration ;  calvarial defect ;  hyperbaric oxygen therapy ; parathyroid hormone
OBJECTIVE: To determine the synergistic effect of parathyroid hormone (PTH) [1-34] in combination with hyperbaric oxygen (HBO) on bone graft in a rat calvarial bone defect model under impaired osteogenic conditions. MATERIALS AND METHODS: Twenty-four rats were divided into three groups. Localized radiation with a single 12 Gy dose was administered to the calvaria. Four weeks after radiation, calvarial circular defects were created in the parietal bones. All defects were filled with biphasic calcium phosphate. After the bone graft, PTH [1-34] was injected subcutaneously, and HBO was administered. At 6 weeks after the bone graft, the rats were sacrificed, and specimens were harvested. RESULTS: Histomorphometric evaluation showed that the percentage of new bone area was higher in the PTH and PTH/HBO groups than in the control group. The percent residual material area was decreased in the PTH/HBO group compared with the control group. The percentage blood vessel number was highest in the PTH group. Micro-CT evaluation showed that the new bone volume was highest in the PTH/HBO group. The residual material volume was lowest in the PTH/HBO group. CONCLUSION: Within the limitations of this study, our data indicate that PTH combined with HBO may reverse radiation-induced impairment of bone healing.
Full Text
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Advanced General Dentistry (통합치의학과) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Park, Wonse(박원서) ORCID logo https://orcid.org/0000-0002-2081-1156
Hu, Kyung Seok(허경석) ORCID logo https://orcid.org/0000-0002-9048-3805
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.