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Psychotic conversion of individuals at ultra-high risk for psychosis: The potential roles of schizotypy and basic symptoms

 Minji Bang  ;  Jin Young Park  ;  Kyung Ran Kim  ;  Su Young Lee  ;  Yun Young Song  ;  Jee In Kang  ;  Eun Lee  ;  Suk Kyoon An 
 EARLY INTERVENTION IN PSYCHIATRY, Vol.13(3) : 546-554, 2019 
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basic symptoms ; physical anhedonia ; schizophrenia ;  schizotypy ;  ultra-high risk for psychosis
AIM: To improve strategies for the early identification of individuals at a heightened risk for the development of psychosis, we investigated the relationships and interactions between 3 psychosis-proneness dimensions for the development of schizophrenia spectrum psychosis: schizotypy, basic symptoms and the ultra-high risk (UHR) criteria. METHODS: Seventy-seven UHR individuals and 79 healthy controls were assessed for schizotypy and basic symptoms using self-report questionnaires at baseline. UHR participants were monthly assessed for conversion to psychosis over a mean period of 25.8 months. RESULTS: Sixteen UHR participants (20.8%) converted to schizophrenia spectrum psychosis. In stepwise Cox regression, the interaction between basic symptoms and physical anhedonia was selected as a sole predictor of conversion in UHR participants, whereby the self-reported number of the 8 basic symptoms significantly increased the risk for conversion in those with pronounced physical anhedonia. CONCLUSION: Our findings suggest that questionnaire-assessed basic symptoms, irrespective of their predictive validity, may predict a psychotic breakdown in pre-identified UHR individuals who are with genetic vulnerability to schizophrenia. Including all 3 psychosis-proneness dimensions into prediction models might help establish a more valid pathogenetic model of schizophrenia, and moreover, may provide some clues about course alteration strategies in hopes of preventing UHR individuals from converting to psychosis.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Park, Jin Young(박진영) ORCID logo https://orcid.org/0000-0002-5351-9549
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
Lee, Eun(이은) ORCID logo https://orcid.org/0000-0002-7462-0144
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