94 158

Cited 0 times in

Inactivation of Sirtuin2 protects mice from acetaminophen-induced liver injury: possibleinvolvement of ER stress and S6K2 activation

Authors
 Da Hyun Lee  ;  Buhyun Lee  ;  Jeong Su Park  ;  Yu Seol Lee  ;  Jin Hee Kim  ;  Yejin Cho  ;  Yoonjung Jo  ;  Hyun-Seok Kim  ;  Yong-ho Lee  ;  Ki Taek Nam  ;  Soo Han Bae 
Citation
 BMB REPORTS, Vol.52(3) : 190-195, 2019 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2019
MeSH
Acetaminophen/adverse effects ; Acetaminophen/pharmacology ; Acetaminophen/toxicity ; Animals ; Chemical and Drug Induced Liver Injury/genetics ; Chemical and Drug Induced Liver Injury/prevention & control ; Endoplasmic Reticulum Stress/physiology ; Hepatocytes/metabolism ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria, Liver/metabolism ; Necrosis ; Oxidative Stress ; Protective Agents ; Ribosomal Protein S6 Kinases, 90-kDa/metabolism ; Ribosomal Protein S6 Kinases, 90-kDa/physiology ; Sirtuin 2/genetics ; Sirtuin 2/metabolism ; Sirtuin 2/physiology
Keywords
Acetaminophen ; ER stress ; Hepatotoxicity ; S6K1 ; Sirtuin3
Abstract
Acetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt3) is an NAD+-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesias well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries.
Files in This Item:
T201901878.pdf Download
DOI
10.5483/BMBRep.2019.52.3.084
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
Bae, Soo Han(배수한) ORCID logo https://orcid.org/0000-0002-8007-2906
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170214
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links