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InactivationofSirtuin2protectsmicefromacetaminophen-inducedliverinjury:possibleinvolvementofERstressandS6K2activation

DC Field Value Language
dc.contributor.author남기택-
dc.contributor.author배수한-
dc.contributor.author이용호-
dc.contributor.author조예진-
dc.contributor.author박정수-
dc.contributor.author이다현-
dc.date.accessioned2019-07-23T06:34:17Z-
dc.date.available2019-07-23T06:34:17Z-
dc.date.issued2019-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170214-
dc.description.abstractAcetaminophen (APAP) overdose can cause hepatotoxicity by inducing mitochondrial damage and subsequent necrosis in hepatocytes. Sirtuin2 (Sirt3) is an NAD+-dependent deacetylase that regulates several biological processes, including hepatic gluconeogenesias well as inflammatory pathways. We show that APAP decreases the expression of Sirt2. Moreover, the ablation of Sirt2 attenuates APAP-induced liver injuries, such as oxidative stress and mitochondrial damage in hepatocytes. We found that Sirt2 deficiency alleviates the APAP-mediated endoplasmic reticulum (ER) stress and phosphorylation of the p70 ribosomal S6 kinase 1 (S6K1). Moreover, Sirt2 interacts with and deacetylates S6K1, followed by S6K1 phosphorylation induction. This study elucidates the molecular mechanisms underlying the protective role of Sirt2 inactivation in APAP-induced liver injuries.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAcetaminophen/adverse effects-
dc.subject.MESHAcetaminophen/pharmacology-
dc.subject.MESHAcetaminophen/toxicity-
dc.subject.MESHAnimals-
dc.subject.MESHChemical and Drug InducedLiverInjury/genetics-
dc.subject.MESHChemical and Drug InducedLiverInjury/prevention & control-
dc.subject.MESHEndoplasmic ReticulumStress/physiology-
dc.subject.MESHHepatocytes/metabolism-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHMale-
dc.subject.MESHMice-
dc.subject.MESHMice, Inbred C57BL-
dc.subject.MESHMitochondria,Liver/metabolism-
dc.subject.MESHNecrosis-
dc.subject.MESHOxidativeStress-
dc.subject.MESHProtective Agents-
dc.subject.MESHRibosomal Protein S6 Kinases, 90-kDa/metabolism-
dc.subject.MESHRibosomal Protein S6 Kinases, 90-kDa/physiology-
dc.subject.MESHSirtuin 2/genetics-
dc.subject.MESHSirtuin 2/metabolism-
dc.subject.MESHSirtuin 2/physiology-
dc.titleInactivationofSirtuin2protectsmicefromacetaminophen-inducedliverinjury:possibleinvolvementofERstressandS6K2activation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentBioMedical Science Institute (의생명과학부)-
dc.contributor.googleauthorDa Hyun Lee-
dc.contributor.googleauthorBuhyun Lee-
dc.contributor.googleauthorJeong Su Park-
dc.contributor.googleauthorYu Seol Lee-
dc.contributor.googleauthorJin Hee Kim-
dc.contributor.googleauthorYejin Cho-
dc.contributor.googleauthorYoonjung Jo-
dc.contributor.googleauthorHyun-Seok Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorKi Taek Nam-
dc.contributor.googleauthorSoo Han Bae-
dc.identifier.doi10.5483/BMBRep.2019.52.3.083-
dc.contributor.localIdA01243-
dc.contributor.localIdA01798-
dc.contributor.localIdA02989-
dc.contributor.localIdA06252-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid30021675-
dc.subject.keywordAcetaminophen-
dc.subject.keywordER stress-
dc.subject.keywordHepatotoxicity-
dc.subject.keywordS6K1-
dc.subject.keywordSirtuin3-
dc.contributor.alternativeNameNam, Ki Taek-
dc.contributor.affiliatedAuthor남기택-
dc.contributor.affiliatedAuthor배수한-
dc.contributor.affiliatedAuthor이용호-
dc.contributor.affiliatedAuthor이다현-
dc.citation.volume52-
dc.citation.number3-
dc.citation.startPage190-
dc.citation.endPage195-
dc.identifier.bibliographicCitationBMB REPORTS, Vol.52(3) : 190-195, 2019-
dc.identifier.rimsid64728-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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