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Predicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity

Authors
 Junghee Ha  ;  Hey Jung Jun  ;  Hyewon Shin  ;  Ick Joong Chung  ;  Eunmie Park  ;  Sung Kil Min  ;  Eunjoo Kim 
Citation
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.17(2) : 200-210, 2019 
Journal Title
 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE 
ISSN
 1738-1088 
Issue Date
2019
Keywords
Child behavior ; Gene-environment interaction ; Maternal behavior ; SLC6A4 protein
Abstract
Objective: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. Methods: Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transporter polymorphism. Results: MNA appeared to exert effects in externalizing (b =5.78, p<0.001) and internalizing problems (b =6.09, p< 0.001). Interaction between SLCA4 polymorphism and MNA showed effects on externalizing (b =-7.62, p<0.01) and internalizing problems (b =-9.77, p<0.01). Children with two short alleles showed considerable differences in both externalizing and internalizing problems according to MNA; however, children with one short allele or none showed relatively few differences in behavior problems due to maternal affectivity. Conclusion: The effect of SLC6A4 polymorphism on child behavior seemed to be moderated by MNA. In addition, the impact of MNA was found to vary based on a child s genetic risk. High MNA may trigger the risk allele while low MNA causes the risk allele to illicit less behavior problems. Children with two short variants of the SLC6A4 gene may benefit from intervention that modulates MNA.
Files in This Item:
T201901850.pdf Download
DOI
10.9758/cpn.2019.17.2.200
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eun Joo(김은주) ORCID logo https://orcid.org/0000-0003-3061-2051
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/170090
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