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Predicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity

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dc.contributor.author김은주-
dc.contributor.author하정희-
dc.date.accessioned2019-07-11T03:41:13Z-
dc.date.available2019-07-11T03:41:13Z-
dc.date.issued2019-
dc.identifier.issn1738-1088-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/170090-
dc.description.abstractObjective: This study aimed to investigate whether maternal negative affectivity (MNA) moderates the effect of genetic polymorphism of SLC6A4 on behavior problems in children. Methods: Study participants comprised 143 preschoolers and their mothers from South Korea. The Childhood Behavior Checklist and Emotionality, Activity, and Sociability adult scale were used to measure child behavior and maternal affectivity. DNA from saliva was genotyped to determine serotonin transporter polymorphism. Results: MNA appeared to exert effects in externalizing (b =5.78, p<0.001) and internalizing problems (b =6.09, p< 0.001). Interaction between SLCA4 polymorphism and MNA showed effects on externalizing (b =-7.62, p<0.01) and internalizing problems (b =-9.77, p<0.01). Children with two short alleles showed considerable differences in both externalizing and internalizing problems according to MNA; however, children with one short allele or none showed relatively few differences in behavior problems due to maternal affectivity. Conclusion: The effect of SLC6A4 polymorphism on child behavior seemed to be moderated by MNA. In addition, the impact of MNA was found to vary based on a child s genetic risk. High MNA may trigger the risk allele while low MNA causes the risk allele to illicit less behavior problems. Children with two short variants of the SLC6A4 gene may benefit from intervention that modulates MNA.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish, Korean-
dc.publisherKorean College of Neuropsychopharmacology-
dc.relation.isPartOfCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titlePredicting Behavior Problems in Korean Preschoolers: Interactions of the SLC6A4 Gene and Maternal Negative Affectivity-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Psychiatry (정신과학교실)-
dc.contributor.googleauthorJunghee Ha-
dc.contributor.googleauthorHey Jung Jun-
dc.contributor.googleauthorHyewon Shin-
dc.contributor.googleauthorIck Joong Chung-
dc.contributor.googleauthorEunmie Park-
dc.contributor.googleauthorSung Kil Min-
dc.contributor.googleauthorEunjoo Kim-
dc.identifier.doi10.9758/cpn.2019.17.2.200-
dc.contributor.localIdA00820-
dc.relation.journalcodeJ00609-
dc.identifier.eissn2093-4327-
dc.identifier.pmid30905120-
dc.subject.keywordChild behavior-
dc.subject.keywordGene-environment interaction-
dc.subject.keywordMaternal behavior-
dc.subject.keywordSLC6A4 protein-
dc.contributor.alternativeNameKim, Eun Joo-
dc.contributor.affiliatedAuthor김은주-
dc.citation.volume17-
dc.citation.number2-
dc.citation.startPage200-
dc.citation.endPage210-
dc.identifier.bibliographicCitationCLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, Vol.17(2) : 200-210, 2019-
dc.identifier.rimsid62163-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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