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Development of a multi-channel NIRS-USG hybrid imaging system for detecting prostate cancer and improving the accuracy of imaging-based diagnosis: a phantom study

 Heejin Bae  ;  Seung-seob Kim  ;  Seungsoo Lee  ;  Hyuna Song  ;  Songhyun Lee  ;  Dalkwon Koh  ;  Jae Gwan Kim  ;  Dae Chul Jung 
 ULTRASONOGRAPHY, Vol.38(2) : 143-148, 2019 
Journal Title
Issue Date
Fusion imaging ; Hybrid probe ; Prostate neoplasms ; Spectroscopy, near-infrared ; Ultrasonography
PURPOSE: This study aimed to develop a multi-channel near-infrared spectroscopy (NIRS) and ultrasonography (USG) fusion imaging system for imaging prostate cancer and to verify its diagnostic capability by applying the hybrid imaging system to a prostate cancer phantom.

METHODS: A multi-channel NIRS system using the near-infrared 785-nm wavelength with 12 channels and four detectors was developed. After arranging the optical fibers around a USG transducer, we performed NIRS imaging and grayscale USG imaging simultaneously. Fusion imaging was obtained by processing incoming signals and the spatial reconstruction of NIRS, which corresponded with grayscale USG acquired at the same time. The NIRS-USG hybrid system was applied to a silicone-based optical phantom of the prostate gland containing prostate cancer to verify its diagnostic capability qualitatively.

RESULTS: The NIRS-USG hybrid imaging system for prostate cancer imaging simultaneously provided anatomical and optical information with 2-dimensional registration. The hybrid imaging system showed more NIR attenuation over the prostate cancer model than over the model of normal prostate tissue. Its diagnostic capability to discriminate a focal area mimicking the optical properties of prostate cancer from the surrounding background mimicking the optical properties of normal prostate tissue was verified by applying the hybrid system to a silicone-based optical phantom of prostate cancer.

CONCLUSION: This study successfully demonstrated that the NIRS-USG hybrid system may serve as a new imaging method for improving the diagnostic accuracy of prostate cancer, with potential utility for future clinical applications.
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1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seung-seob(김승섭) ORCID logo https://orcid.org/0000-0001-6071-306X
Bae, Heejin(배희진) ORCID logo https://orcid.org/0000-0002-1227-8646
Lee, Seung Soo(이승수) ORCID logo https://orcid.org/0000-0002-6268-575X
Jung, Dae Chul(정대철) ORCID logo https://orcid.org/0000-0001-5769-5083
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