0 91

Cited 0 times in

The added prognostic value of radiological phenotype combined with clinical features and molecular subtype in anaplastic gliomas

Authors
 Minsu Lee  ;  Kyunghwa Han  ;  Sung Soo Ahn  ;  Sohi Bae  ;  Yoon Seong Choi  ;  Je Beom Hong  ;  Jong Hee Chang  ;  Se Hoon Kim  ;  Seung-Koo Lee 
Citation
 JOURNAL OF NEURO-ONCOLOGY, Vol.142(1) : 129-138, 2019 
Journal Title
 JOURNAL OF NEURO-ONCOLOGY 
ISSN
 0167-594X 
Issue Date
2019
MeSH
Adult ; Aged ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/genetics ; Brain Neoplasms/radiotherapy* ; Female ; Glioma/diagnostic imaging ; Glioma/genetics ; Glioma/radiotherapy* ; Humans ; Isocitrate Dehydrogenase/genetics* ; Male ; Middle Aged ; Mutation ; Phenotype ; Prognosis ; Retrospective Studies ; Risk Assessment ; Survival Rate ; Young Adult
Keywords
Anaplastic glioma ; IDH mutation ; Imaging biomarker ; LASSO ; Molecular subtype ; VASARI
Abstract
PURPOSE: To determine whether radiological phenotype can improve the predictive performance of the risk model based on molecular subtype and clinical risk factors in anaplastic glioma patients. METHODS: This retrospective study was approved by our institutional review board with waiver of informed consent. MR images of 86 patients with pathologically diagnosed anaplastic glioma (WHO grade III) between January 2007 and February 2016 were analyzed according to the Visually Accessible Rembrandt Images (VASARI) features set. Significant imaging findings were selected to generate a radiological risk score (RRS) for overall survival (OS) and progression-free survival (PFS) using the least absolute shrinkage and selection operator (LASSO) Cox regression model. The prognostic value of RRS was evaluated with multivariate Cox regression including molecular subtype and clinical risk factors. The C-indices of multivariate models with and without RRS were compared by bootstrapping. RESULTS: Eight VASARI features contributed to RRS for OS and six contributed to PFS. Multifocality or multicentricity was the most influential feature, followed by restricted diffusion. RRS was significantly associated with OS and PFS (P < .001), as well as age and molecular subtype. The multivariate model with RRS demonstrated a significantly higher predictive performance than the model without (C-index difference: 0.074, 95% confidence interval [CI]: 0.031, 0.148 for OS; C-index difference: 0.054, 95% CI: 0.014, 0.123 for PFS). CONCLUSION: RRS derived from VASARI features was an independent predictor of survival in patients with anaplastic gliomas. The addition of RRS significantly improved the predictive performance of the molecular feature based model.
Full Text
https://link.springer.com/article/10.1007%2Fs11060-018-03072-0
DOI
10.1007/s11060-018-03072-0
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Se Hoon(김세훈) ORCID logo https://orcid.org/0000-0001-7516-7372
Bae, Sohi(배소희)
Ahn, Sung Soo(안성수) ORCID logo https://orcid.org/0000-0002-0503-5558
Lee, Seung Koo(이승구) ORCID logo https://orcid.org/0000-0001-5646-4072
Chang, Jong Hee(장종희)
Choi, Yoon Seong(최윤성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169959
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse