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Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study

Authors
 Na Young Kim  ;  Jae Chul Koh  ;  Ki-Young Lee  ;  Sung Soo Kim  ;  Jung Hwa Hong  ;  Hoon Jae Nam  ;  Sun-Joon Bai 
Citation
 JOURNAL OF CLINICAL ANESTHESIA, Vol.57 : 97-102, 2019 
Journal Title
 JOURNAL OF CLINICAL ANESTHESIA 
ISSN
 0952-8180 
Issue Date
2019
Keywords
Anesthesia recovery period ; Neostigmine ; Neuromuscular blockade ; Sugammadex
Abstract
STUDY OBJECTIVE: To evaluate the influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium after pars plana vitrectomy (PPV) under general anesthesia. DESIGN: Prospective, double-blind, randomized controlled trial. SETTING: This study was conducted in a University Teaching Hospital from February to July 2017. PATIENTS: A total of 84 patients with an American Society of Anesthesiologists physical status of I or II who were scheduled to undergo PPV under general anesthesia. INTERVENTIONS: The patients were randomly assigned to the neostigmine (Group N, n = 44) or sugammadex (Group S, n = 40) groups; 3 ml of study drug was prepared for the patients. For patients in Group N, a solution of neostigmine methylsulfate (1 mg) and glycopyrrolate (0.2 mg) was prepared, while a solution of sugammadex sodium (2 mg/kg) and normal saline was prepared for patients in Group S. MEASUREMENTS: The primary endpoint was the effect of sugammadex, compared with neostigmine, on the recovery rate in the physiological domain in patients who underwent PPV with general anesthesia. The quality of recovery was assessed using the Postoperative Quality Recovery Scale at 15 min and 40 min after surgery, and on postoperative day 1. MAIN RESULTS: The recovery rate in the physiological domain was higher in Group S at 15 min after surgery (P = 0.020). Though there were no significant differences in the overall cognitive recovery domain, patients in Group S could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the scale. CONCLUSIONS: The use of sugammadex may increase the quality of physiological recovery at early postoperative periods, compared with that of neostigmine, following a single bolus dose of rocuronium in patients undergoing PPV with general anesthesia. TRIAL REGISTRATION: Registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03108989). Registration number: NCT03108989.
Full Text
https://www.sciencedirect.com/science/article/pii/S0952818018317306
DOI
10.1016/j.jclinane.2019.02.014
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Na Young(김나영) ORCID logo https://orcid.org/0000-0003-3685-2005
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Nam, Hoon Jae(남훈재) ORCID logo https://orcid.org/0000-0001-7112-9221
Bai, Sun Joon(배선준) ORCID logo https://orcid.org/0000-0001-5027-3232
Lee, Ki Young(이기영) ORCID logo https://orcid.org/0000-0003-4893-3195
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169954
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