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Influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study

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dc.contributor.author김나영-
dc.contributor.author김성수-
dc.contributor.author남훈재-
dc.contributor.author배선준-
dc.contributor.author이기영-
dc.date.accessioned2019-07-11T03:23:04Z-
dc.date.available2019-07-11T03:23:04Z-
dc.date.issued2019-
dc.identifier.issn0952-8180-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/169954-
dc.description.abstractSTUDY OBJECTIVE: To evaluate the influence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium after pars plana vitrectomy (PPV) under general anesthesia. DESIGN: Prospective, double-blind, randomized controlled trial. SETTING: This study was conducted in a University Teaching Hospital from February to July 2017. PATIENTS: A total of 84 patients with an American Society of Anesthesiologists physical status of I or II who were scheduled to undergo PPV under general anesthesia. INTERVENTIONS: The patients were randomly assigned to the neostigmine (Group N, n = 44) or sugammadex (Group S, n = 40) groups; 3 ml of study drug was prepared for the patients. For patients in Group N, a solution of neostigmine methylsulfate (1 mg) and glycopyrrolate (0.2 mg) was prepared, while a solution of sugammadex sodium (2 mg/kg) and normal saline was prepared for patients in Group S. MEASUREMENTS: The primary endpoint was the effect of sugammadex, compared with neostigmine, on the recovery rate in the physiological domain in patients who underwent PPV with general anesthesia. The quality of recovery was assessed using the Postoperative Quality Recovery Scale at 15 min and 40 min after surgery, and on postoperative day 1. MAIN RESULTS: The recovery rate in the physiological domain was higher in Group S at 15 min after surgery (P = 0.020). Though there were no significant differences in the overall cognitive recovery domain, patients in Group S could recall more numbers in reverse order. However, there were no significant differences between the groups in the other domains of the scale. CONCLUSIONS: The use of sugammadex may increase the quality of physiological recovery at early postoperative periods, compared with that of neostigmine, following a single bolus dose of rocuronium in patients undergoing PPV with general anesthesia. TRIAL REGISTRATION: Registered at ClinicalTrials.gov (https://clinicaltrials.gov/ct2/show/NCT03108989). Registration number: NCT03108989.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF CLINICAL ANESTHESIA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleInfluence of reversal of neuromuscular blockade with sugammadex or neostigmine on postoperative quality of recovery following a single bolus dose of rocuronium: A prospective, randomized, double-blinded, controlled study-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorNa Young Kim-
dc.contributor.googleauthorJae Chul Koh-
dc.contributor.googleauthorKi-Young Lee-
dc.contributor.googleauthorSung Soo Kim-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorHoon Jae Nam-
dc.contributor.googleauthorSun-Joon Bai-
dc.identifier.doi10.1016/j.jclinane.2019.02.014-
dc.contributor.localIdA00348-
dc.contributor.localIdA00571-
dc.contributor.localIdA00571-
dc.contributor.localIdA05552-
dc.contributor.localIdA05552-
dc.contributor.localIdA01795-
dc.contributor.localIdA01795-
dc.contributor.localIdA02695-
dc.contributor.localIdA02695-
dc.relation.journalcodeJ01315-
dc.identifier.eissn1873-4529-
dc.identifier.pmid30939422-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0952818018317306-
dc.subject.keywordAnesthesia recovery period-
dc.subject.keywordNeostigmine-
dc.subject.keywordNeuromuscular blockade-
dc.subject.keywordSugammadex-
dc.contributor.alternativeNameKim, Na Young-
dc.contributor.affiliatedAuthor김나영-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor김성수-
dc.contributor.affiliatedAuthor남훈재-
dc.contributor.affiliatedAuthor남훈재-
dc.contributor.affiliatedAuthor배선준-
dc.contributor.affiliatedAuthor배선준-
dc.contributor.affiliatedAuthor이기영-
dc.contributor.affiliatedAuthor이기영-
dc.citation.volume57-
dc.citation.startPage97-
dc.citation.endPage102-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL ANESTHESIA, Vol.57 : 97-102, 2019-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers

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