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Preoperative controlling nutritional status (CONUT) score as a novel immune-nutritional predictor of survival in non-metastatic clear cell renal cell carcinoma of ≤ 7 cm on preoperative imaging

Authors
 Ahmed Elghiaty  ;  Jongchan Kim  ;  Won Sik Jang  ;  Jee Soo Park  ;  Ji Eun Heo  ;  Koon Ho Rha  ;  Young Deuk Choi  ;  Won Sik Ham 
Citation
 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, Vol.145(4) : 957-965, 2019 
Journal Title
 JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 
ISSN
 0171-5216 
Issue Date
2019
MeSH
Adult ; Aged ; Aged, 80 and over ; Carcinoma, Renal Cell/blood ; Carcinoma, Renal Cell/immunology ; Carcinoma, Renal Cell/mortality ; Carcinoma, Renal Cell/surgery* ; Cholesterol/blood ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Kidney Neoplasms/blood ; Kidney Neoplasms/immunology ; Kidney Neoplasms/mortality ; Kidney Neoplasms/surgery* ; Lymphocyte Count ; Male ; Middle Aged ; Nephrectomy ; Nutritional Status* ; Predictive Value of Tests ; Preoperative Period ; Retrospective Studies ; Serum Albumin/metabolism
Keywords
Immunity ; Nephrectomy ; Non-metastatic clear cell renal cell carcinoma ; Nutrition
Abstract
PURPOSE: This study aimed at investigating the prognostic value of Preoperative controlling nutritional status (CONUT) score in non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging. METHODS: We retrospectively included 1046 among 1637 patients who underwent radical or partial nephrectomy for solid renal masses ≤ 7 cm (2005-2014) after excluding other pathology, conditions affecting CONUT score components, metastasis, regional lymphadenopathy, positive margin, and follow-up < 12 months. We defined high and low CONUT according to cut-off of (2). Multivariate Cox-regression analysis was used to predict factors affecting recurrence and survival. Kaplan-Meier curve was used for survival analysis. RESULTS: The median age and follow-up were 56 years and 63 months, respectively. 41 patients had recurrence (3.9%). CONUT was a predictor for recurrence-free, cancer-specific, and overall survival (HR 3.09, P = 0.003 and HR 4.66, P = 0.004 and HR 2.81, P = 0.003, respectively). A higher CONUT was significantly associated with worse 5 years recurrence-free (88.2% vs. 97.1%), cancer-specific (96.2% vs. 98.8%) and overall (90.9% vs. 96.5%) survival (log-rank, P = < 0.001, P = 0.006 and P = < 0.001, respectively). CONCLUSIONS: The preoperative CONUT is an independent prognostic marker for survival after curative surgery for non-metastatic clear-cell renal cell carcinoma of ≤ 7 cm on preoperative imaging.
Full Text
https://link.springer.com/article/10.1007%2Fs00432-019-02846-x
DOI
10.1007/s00432-019-02846-x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Chan(김종찬) ORCID logo https://orcid.org/0000-0002-0022-6689
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Park, Jee Soo(박지수) ORCID logo https://orcid.org/0000-0001-9976-6599
Jang, Won Sik(장원식) ORCID logo https://orcid.org/0000-0002-9082-0381
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
Heo, Ji Eun(허지은) ORCID logo https://orcid.org/0000-0002-4184-8468
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/169845
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