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Incremental Role of Pancreatic Magnetic Resonance Imaging after Staging Computed Tomography to Evaluate Patients with Pancreatic Ductal Adenocarcinoma

 Hye Jin Kim  ;  Mi-Suk Park  ;  Jin Yong Lee  ;  Kyunghwa Han  ;  Yong Eun Chung  ;  Jin-Young Choi  ;  Myeong-Jin Kim  ;  Chang Moo Kang 
 CANCER RESEARCH AND TREATMENT, Vol.51(1) : 24-33, 2019 
Journal Title
Issue Date
Aged ; Carcinoma, Pancreatic Ductal/diagnostic imaging* ; Carcinoma, Pancreatic Ductal/pathology* ; Carcinoma, Pancreatic Ductal/surgery ; Cohort Studies ; Disease Progression ; Female ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/secondary* ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multimodal Imaging ; Neoplasm Staging ; Pancreatic Neoplasms/diagnostic imaging* ; Pancreatic Neoplasms/pathology* ; Pancreatic Neoplasms/surgery ; Prognosis ; Survival Analysis ; Time Factors ; Tomography, X-Ray Computed
Computed tomography ; Magnetic resonance imaging ; Pancreas ductal adenocarcinoma ; Resectability
PURPOSE: The purpose of this study was to investigate the impact of contrast enhanced pancreatic magnetic resonance imaging (MRI) in resectability and prognosis evaluation after staging computed tomography (CT) in patients with pancreatic ductal adenocarcinoma (PDA). Materials and Methods: From January 2005 to December 2012, 298 patients were diagnosed to have potentially resectable stage PDA on CT. Patients were divided into CT+MR (patients underwent both CT and MRI; n=216) and CT only groups (n=82). Changes in resectability staging in the CT+MR group were evaluated. The overall survival was compared between the two groups. The recurrence-free survival and median time to liver metastasis after curative surgery were compared between the two groups. RESULTS: Staging was changed from resectable on CT to unresectable state on MRI in 14.4% of (31 of 216 patients) patients of the CT+MR group. The overall survival and recurrence-free survival rates were not significantly different between the two groups (p=0.162 and p=0.721, respectively). The median time to liver metastases after curative surgery in the CT+MR group (9.9 months) was significantly longer than that in the CT group (4.2 months) (p=0.011). CONCLUSION: Additional MRI resulted in changes of resectability and treatment modifications in a significant proportion of patients who have potentially resectable state at CT and in prolonged time to liver metastases in patients after curative surgery. Additional MRI to standard staging CT can be recommended for surgical candidates of PDA.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Chang Moo(강창무) ORCID logo https://orcid.org/0000-0002-5382-4658
Kim, Myeong Jin(김명진) ORCID logo https://orcid.org/0000-0001-7949-5402
Park, Mi-Suk(박미숙) ORCID logo https://orcid.org/0000-0001-5817-2444
Chung, Yong Eun(정용은) ORCID logo https://orcid.org/0000-0003-0811-9578
Choi, Jin Young(최진영) ORCID logo https://orcid.org/0000-0002-9025-6274
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