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백질변성이 섬망의 심각도 및 경과에 미치는 영향

Other Titles
 The Effect of Leukoaraiosis on the Severity and Course of Delirium 
 최원정  ;  석정호  ;  오승택  ;  정태섭  ;  김재진 
 Korean Journal of Psychosomatic Medicine (정신신체의학), Vol.26(2) : 194-200, 2018 
Journal Title
 Korean Journal of Psychosomatic Medicine (정신신체의학) 
Issue Date
Delirium ; Brain magnetic resonance imaging ; Leukoaraiosis ; Periventricular hyperintensity ; Deep white matter hyperintensity
Objectives:The significance of leukoaraiosis on brain magnetic resonance imaging (MRI) is uncertain, but it is often seen with vascular risk factors or in the context of cognitive impairment. We aimed to investigate the effect of leukoaraiosis on the severity and course of delirium. Methods:Periventricular hyperintensity and deep white matter hyperintensity on brain MRI were rated in 42 patients with delirium by semiquantative visual rating scale. Correlations between their grades and the scores of Korean version of Delirium Rating Scale-Revised-98 (K-DRS-R-98) were analyzed, and the interaction effects between the groups according to the levels of leukoaraiosis and two evaluation points were also analyzed. Results:The grade of deep white matter hyperintensity in the occipital lobe was positively correlated with the scores on the total, severity items, cognitive items, and non-cognitive items of K-DRS-R-98. The cognitive items scores of K-DRS-R-98 in the low grade group of periventricular hyperintensity showed significantly steeper decrease than the high grade group. Conclusions:A difference in severity or recovery speed of delirium according to the level of leukoaraiosis may result from disruption in brain functional connectivity. Our results have a clinical implication in that the severity and course of delirium can be possibly predicted using the level of leukoaraiosis.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Seok, Jeong Ho(석정호) ORCID logo https://orcid.org/0000-0002-9402-7591
Chung, Tae Sub(정태섭)
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