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Increased Expression of the Matrix-Modifying Enzyme Lysyl Oxidase-Like 2 in Aggressive Hepatocellular Carcinoma with Poor Prognosis

Authors
 Jiwoon Choi  ;  Taek Chung  ;  Hyungjin Rhee  ;  Young-Joo Kim  ;  Youngsic Jeon  ;  Jeong Eun Yoo  ;  Songmi Noh  ;  Dai Hoon Han  ;  Young Nyun Park 
Citation
 Gut and Liver, Vol.13(1) : 83-92, 2019 
Journal Title
 Gut and Liver 
ISSN
 1976-2283 
Issue Date
2019
Keywords
Carcinoma, hepatocellular ; Extracellular matrix ; LOXL2 ; Prognosis
Abstract
Background/Aims: Lysyl oxidase-like 2 (LOXL2), a collagen-modifying enzyme, has been implicated in cancer invasiveness and metastasis. Methods: We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry. Results: LOXL2 positivity was found in 14.3% (15/105) of HCCs, and it was significantly associated with high serum α-fetoprotein levels, poor differentiation, fibrous stroma, portal vein invasion, and advanced TNM stage (p<0.05 for all). Additionally, LOXL2 positivity was significantly associated with CAIX (p=0.005) and stromal interleukin 6 expression (p=0.001). Survival analysis of 99 HCC patients revealed LOXL2 positivity to be a poor prognostic factor; its prognostic impact appeared in progressed HCCs. Furthermore, LOXL2 positivity was shown to be an independent predictor of overall survival and disease-specific survival (p<0.05 for all). Interestingly, co-expression of LOXL2 and CAIX was also an independent predictor for overall survival, disease-specific survival, disease-free survival, and extrahepatic recurrence-free survival (p<0.05 for all). Conclusions: LOXL2 expression represents a subgroup of HCCs with more aggressive behavior and is suggested to be a poor prognostic marker in HCC patients.
DOI
10.5009/gnl17569
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
박영년(Park, Young Nyun) ORCID logo https://orcid.org/0000-0003-0357-7967
유정은(Yoo, Jeong Eun) ORCID logo https://orcid.org/0000-0001-9990-279X
이형진(Rhee, Hyungjin) ORCID logo https://orcid.org/0000-0001-7759-4458
정택(Chung, Taek) ORCID logo https://orcid.org/0000-0001-7567-0680
한대훈(Han, Dai Hoon) ORCID logo https://orcid.org/0000-0003-2787-7876
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167563
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