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Diagnostic accuracy of low-radiation coronary computed tomography angiography with low tube voltage and knowledge-based model reconstruction

Authors
 Joohee Lee  ;  Tae Hoon Kim  ;  Byoung Kwon Lee  ;  Young Won Yoon  ;  Hyuck Moon Kwon  ;  Bum Kee Hong  ;  Pil-Ki Min  ;  Eui-Young Choi  ;  Chi Suk Oh  ;  Chul Hwan Park 
Citation
 Scientific Reports, Vol.9(1) : 1308, 2019 
Journal Title
 Scientific Reports 
Issue Date
2019
Abstract
We aimed to evaluate the accuracy of coronary computed tomography angiography (CCTA) with a low-radiation protocol and iterative model reconstruction (IMR), in comparison with invasive coronary angiography (ICA). Sixty-one patients (45 males; mean age, 61.9 ± 9.2 years) with suspected coronary artery disease who underwent CCTA and ICA were retrospectively enrolled. CCTA was performed with low tube voltage (80 or 100 kVp), low tube current (100-200 mAs), prospective ECG triggering, and IMR using a 64-slice computed tomography scanner. Coronary artery disease was defined as luminal narrowing of >50%, as assessed using CCTA and ICA. The sensitivity, specificity, positive (PPV) and negative (NPV) predictive value, and accuracy of CCTA were examined. The mean radiation dose of CCTA was 1.05 ± 0.36 mSv. No non-diagnostic segment was noted. The sensitivity, specificity, PPV, NPV, and accuracy of CCTA were 86.4%, 96.1%, 80.3%, 97.5%, and 94.6% on a per segment basis, 93.1%, 94.7%, 88.3%, 97.0%, and 94.2% on a per vessel basis, and 100%, 83.3%, 93.5%, 100%, and 95.1% on a per patient basis, respectively. In conclusion, a low-radiation CCTA protocol with IMR may be useful for diagnosing coronary artery disease, as it reduces the radiation dose while maintaining diagnostic accuracy.
Files in This Item:
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DOI
10.1038/s41598-018-37870-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김태훈(Kim, Tae Hoon) ORCID logo https://orcid.org/0000-0003-3598-2529
민필기(Min, Pil Ki) ORCID logo https://orcid.org/0000-0001-7033-7651
박철환(Park, Chul Hwan) ORCID logo https://orcid.org/0000-0002-0004-9475
오치석(Oh, Chi Suk)
윤영원(Yoon, Young Won) ORCID logo https://orcid.org/0000-0002-0907-0350
이병권(Lee, Byoung Kwon) ORCID logo https://orcid.org/0000-0001-9259-2776
이주희(Lee, Joohee) ORCID logo https://orcid.org/0000-0002-7721-8935
최의영(Choi, Eui Young) ORCID logo https://orcid.org/0000-0003-3732-0190
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167519
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