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Novel anti-biofouling light-curable fluoride varnish containing 2-methacryloyloxyethyl phosphorylcholine to prevent enamel demineralization

DC FieldValueLanguage
dc.contributor.author권재성-
dc.contributor.author김광만-
dc.contributor.author김도현-
dc.contributor.author장성일-
dc.contributor.author최성환-
dc.contributor.author황충주-
dc.contributor.author김광만-
dc.contributor.author김도현-
dc.contributor.author장성일-
dc.contributor.author최성환-
dc.contributor.author황충주-
dc.date.accessioned2019-03-15T02:25:00Z-
dc.date.available2019-03-15T02:25:00Z-
dc.date.issued2019-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/167452-
dc.description.abstractWe evaluated the efficacy of light-curable fluoride varnish (LCFV) that contains 2-methacryloyloxyethyl phosphorylcholine (MPC) in terms of anti-biofouling properties and prevention of tooth enamel demineralization. MPC was mixed with and incorporated into LCFV at 0 (control), 1.5, 3.0, 5.0, 10.0, 20.0, and 40.0 weight percentage (wt%). Addition of high wt% of MPC resulted in increased film thickness and decreased the degree of conversion, indicating loss of the advantageous properties of LCFV. Addition of 1.5, 3, or 5 wt% MPC significantly reduced the amount of bovine serum albumin adsorbed from a solution and proteins adsorbed from brain heart infusion medium compared to the control (P < 0.001). A similar pattern was observed for bacterial adhesion: significantly less Streptococcus mutans cells adhered on the surface of LCFV with 1.5, 3, or 5 wt% MPC (P < 0.001) than on the control, and similar results were obtained for Actinomyces naeslundii and Streptococcus sanguinis adherence to LCFV with 3 wt% MPC. Finally, bacterial adhesion, surface microhardness loss, and the depth of demineralization were substantially lower on bovine tooth enamel surface coated with LCFV containing 3 wt% of MPC than in the control treatment (0 wt% MPC). Therefore, this novel LCFV containing a low concentration of MPC (e.g., 3 wt%) would be effective in anti-biofouling while maintaining the important advantageous features of light-curable fluoride in preventing demineralization.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfScientific Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleNovel anti-biofouling light-curable fluoride varnish containing 2-methacryloyloxyethyl phosphorylcholine to prevent enamel demineralization-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실)-
dc.contributor.googleauthorJae-Sung Kwon-
dc.contributor.googleauthorMyung-Jin Lee-
dc.contributor.googleauthorJi-Young Kim-
dc.contributor.googleauthorDohyun Kim-
dc.contributor.googleauthorJeong-Hyun Ryu-
dc.contributor.googleauthorSungil Jang-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorChung-Ju Hwang-
dc.contributor.googleauthorSung-Hwan Choi-
dc.identifier.doi10.1038/s41598-018-38255-2-
dc.contributor.localIdA00247-
dc.contributor.localIdA00312-
dc.contributor.localIdA00312-
dc.contributor.localIdA00389-
dc.contributor.localIdA00389-
dc.contributor.localIdA03440-
dc.contributor.localIdA03440-
dc.contributor.localIdA04083-
dc.contributor.localIdA04083-
dc.contributor.localIdA04492-
dc.contributor.localIdA04492-
dc.contributor.localIdA00312-
dc.contributor.localIdA00312-
dc.contributor.localIdA00389-
dc.contributor.localIdA00389-
dc.contributor.localIdA03440-
dc.contributor.localIdA03440-
dc.contributor.localIdA04083-
dc.contributor.localIdA04083-
dc.contributor.localIdA04492-
dc.contributor.localIdA04492-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid30723241-
dc.contributor.alternativeNameKwon, Jae-Sung-
dc.contributor.affiliatedAuthor권재성-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김도현-
dc.contributor.affiliatedAuthor김도현-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor황충주-
dc.contributor.affiliatedAuthor황충주-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김광만-
dc.contributor.affiliatedAuthor김도현-
dc.contributor.affiliatedAuthor김도현-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor장성일-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor최성환-
dc.contributor.affiliatedAuthor황충주-
dc.contributor.affiliatedAuthor황충주-
dc.citation.volume9-
dc.citation.number1-
dc.citation.startPage1432-
dc.identifier.bibliographicCitationScientific Reports, Vol.9(1) : 1432, 2019-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Conservative Dentistry (보존과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Orthodontics (교정과학교실) > 1. Journal Papers

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