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Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes

Authors
 Hyeonhui Kim  ;  Minki Kim  ;  Sun-Kyoung Im  ;  Sungsoon Fang 
Citation
 Laboratory Animal Research, Vol.34(4) : 147-159, 2018 
Journal Title
 Laboratory Animal Research 
ISSN
 1738-6055 
Issue Date
2018
Keywords
Cre portal sites ; Cre-loxP system ; tissue specific promoter
Abstract
Genetically engineered mouse models are commonly preferred for studying the human disease due to genetic and pathophysiological similarities between mice and humans. In particular, Cre-loxP system is widely used as an integral experimental tool for generating the conditional. This system has enabled researchers to investigate genes of interest in a tissue/cell (spatial control) and/or time (temporal control) specific manner. A various tissue-specific Cre-driver mouse lines have been generated to date, and new Cre lines are still being developed. This review provides a brief overview of Cre-loxP system and a few commonly used promoters for expression of tissue-specific Cre recombinase. Also, we finally introduce some available links to the Web sites that provides detailed information about Cre mouse lines including their characterization.
Files in This Item:
T201805447.pdf Download
DOI
10.5625/lar.2018.34.4.147
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Im, Sun-Kyoung(임선경)
Fang, Sungsoon(황성순) ORCID logo https://orcid.org/0000-0003-0201-5567
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/167279
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